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4-hydroperoxy cyclophosphamide

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Catalog No. T35643Cas No. 39800-16-3
Alias 4-OOH-CY, 4-OOH Cyclophosphamid, 4-Hydroperoxycyclophosphamide

4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases.

4-hydroperoxy cyclophosphamide

4-hydroperoxy cyclophosphamide

😃Good
Catalog No. T35643Alias 4-OOH-CY, 4-OOH Cyclophosphamid, 4-HydroperoxycyclophosphamideCas No. 39800-16-3
4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$24935 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases.
In vitro
4-hydroperoxy cyclophosphamide mediates caspase-independent T cell apoptosis through oxidative stress-induced nuclear relocalization of mitochondrial apoptotic factors AIF and EndoG. [1]
The combination of 1 μg/mL 4-hydroperoxy cyclophosphamide and methotrexate inhibited IL-6/sil-6r-induced RANKL expression in fibroblast-like synoviocytes through inhibition of JAK2/STAT3 and p38MAPK signaling pathways. [2]
In vivo
Intraperitoneal injection of 200 mg/kg 4-hydroperoxy cyclophosphamide resulted in caspase-independent T and B cell death in mice. [1]
Synonyms4-OOH-CY, 4-OOH Cyclophosphamid, 4-Hydroperoxycyclophosphamide
Chemical Properties
Molecular Weight293.09
FormulaC7H15Cl2N2O4P
Cas No.39800-16-3
SmilesO=P1(OCCC(OO)N1)N(CCCl)CCCl
Storage & Solubility Information
Storagestore at low temperature,store under nitrogen,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Dichloromethane: <1 mg/mL(insoluble or slightly soluble)
DMSO: 30 mg/mL (102.36 mM), Sonication is recommended.
Chloroform: <1 mg/mL(insoluble or slightly soluble)
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.82 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4119 mL17.0596 mL34.1192 mL170.5961 mL
5 mM0.6824 mL3.4119 mL6.8238 mL34.1192 mL
10 mM0.3412 mL1.7060 mL3.4119 mL17.0596 mL
20 mM0.1706 mL0.8530 mL1.7060 mL8.5298 mL
50 mM0.0682 mL0.3412 mL0.6824 mL3.4119 mL
100 mM0.0341 mL0.1706 mL0.3412 mL1.7060 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Keywords

ROSReactiveOxygenSpeciesReactive Oxygen SpeciesDrugMetaboliteDrug MetaboliteDNAAlkylatorDNA Alkylator/CrosslinkerDNA AlkylatorCrosslinkerApoptosis4-hydroperoxy Cyclophosphamide4hydroperoxy Cyclophosphamide4 hydroperoxy Cyclophosphamide
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