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4-hydroperoxy cyclophosphamide
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Catalog No. T35643Cas No. 39800-16-3
Alias 4-OOH-CY, 4-OOH Cyclophosphamid, 4-Hydroperoxycyclophosphamide
4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases.
4-hydroperoxy cyclophosphamide
😃Good
Catalog No. T35643Alias 4-OOH-CY, 4-OOH Cyclophosphamid, 4-HydroperoxycyclophosphamideCas No. 39800-16-3
4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $249 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | 4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases. |
| In vitro | 4-hydroperoxy cyclophosphamide mediates caspase-independent T cell apoptosis through oxidative stress-induced nuclear relocalization of mitochondrial apoptotic factors AIF and EndoG. [1] The combination of 1 μg/mL 4-hydroperoxy cyclophosphamide and methotrexate inhibited IL-6/sil-6r-induced RANKL expression in fibroblast-like synoviocytes through inhibition of JAK2/STAT3 and p38MAPK signaling pathways. [2] |
| In vivo | Intraperitoneal injection of 200 mg/kg 4-hydroperoxy cyclophosphamide resulted in caspase-independent T and B cell death in mice. [1] |
| Synonyms | 4-OOH-CY, 4-OOH Cyclophosphamid, 4-Hydroperoxycyclophosphamide |
| Molecular Weight | 293.09 |
| Formula | C7H15Cl2N2O4P |
| Cas No. | 39800-16-3 |
| Smiles | O=P1(OCCC(OO)N1)N(CCCl)CCCl |
Storage & Solubility Information
| Storage | store at low temperature,store under nitrogen,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Dichloromethane: <1 mg/mL(insoluble or slightly soluble) DMSO: 30 mg/mL (102.36 mM), Sonication is recommended. Chloroform: <1 mg/mL(insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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