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4-hydroperoxy cyclophosphamide

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Catalog No. T35643Cas No. 39800-16-3
Alias 4-OOH-CY, 4-OOH Cyclophosphamid, 4-Hydroperoxycyclophosphamide

4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases.

4-hydroperoxy cyclophosphamide

4-hydroperoxy cyclophosphamide

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Purity: 98%
Catalog No. T35643Alias 4-OOH-CY, 4-OOH Cyclophosphamid, 4-HydroperoxycyclophosphamideCas No. 39800-16-3
4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$24935 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98%
Appearance:Viscous
Color:Yellow
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Product Introduction

Bioactivity
Description
4-hydroperoxy cyclophosphamide (4-OOH-CY) is an active metabolite of Cyclophosphamide that induces hepatotoxicity.4-Hydroperoxy cyclophosphamide increases levels of glutaminase and aspartate aminotransferase, enhances inflammatory factors and oxidative markers, and Inhibits oxidoreductase activity.4-Hydroperoxy cyclophosphamide is used in the study of cancer and autoimmune diseases.
In vitro
4-hydroperoxy cyclophosphamide mediates caspase-independent T cell apoptosis through oxidative stress-induced nuclear relocalization of mitochondrial apoptotic factors AIF and EndoG. [1]
The combination of 1 μg/mL 4-hydroperoxy cyclophosphamide and methotrexate inhibited IL-6/sil-6r-induced RANKL expression in fibroblast-like synoviocytes through inhibition of JAK2/STAT3 and p38MAPK signaling pathways. [2]
In vivo
Intraperitoneal injection of 200 mg/kg 4-hydroperoxy cyclophosphamide resulted in caspase-independent T and B cell death in mice. [1]
Synonyms4-OOH-CY, 4-OOH Cyclophosphamid, 4-Hydroperoxycyclophosphamide
Chemical Properties
Molecular Weight293.09
FormulaC7H15Cl2N2O4P
Cas No.39800-16-3
SmilesO=P1(OCCC(OO)N1)N(CCCl)CCCl
Storage & Solubility Information
Storagestore at low temperature,store under nitrogen,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Dichloromethane: <1 mg/mL(insoluble or slightly soluble)
DMSO: 30 mg/mL (102.36 mM), Sonication is recommended.
Chloroform: <1 mg/mL(insoluble or slightly soluble)
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.82 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4119 mL17.0596 mL34.1192 mL170.5961 mL
5 mM0.6824 mL3.4119 mL6.8238 mL34.1192 mL
10 mM0.3412 mL1.7060 mL3.4119 mL17.0596 mL
20 mM0.1706 mL0.8530 mL1.7060 mL8.5298 mL
50 mM0.0682 mL0.3412 mL0.6824 mL3.4119 mL
100 mM0.0341 mL0.1706 mL0.3412 mL1.7060 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ROSReactiveOxygenSpeciesReactive Oxygen SpeciesDrugMetaboliteDrug MetaboliteDNAAlkylatorDNA Alkylator/CrosslinkerDNA AlkylatorCrosslinkerApoptosis4-hydroperoxy Cyclophosphamide4hydroperoxy Cyclophosphamide4 hydroperoxy Cyclophosphamide
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