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Epirubicin

Name: Epirubicin
Brand: TargetMol
SKU: T69093
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69093Cas No. 56420-45-2

Alias IMI 28, epi DX, 4-epidoxorubicin, 4'-Epidoxorubicin, 4-epiadriamycin, 4-epi DX

Epirubicin (4'-Epidoxorubicin) is an anthracycline antibiotic that acts as a Topoisomerase II inhibitor. It exerts its antitumor effects by intercalating into DNA base pairs, inhibiting DNA replication and transcription, and inducing DNA strand breaks/apoptosis. Epirubicin is widely used in the treatment of breast, gastric, lung, and ovarian cancers.

Epirubicin

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Purity: 99.82%

Catalog No. T69093Alias IMI 28, epi DX, 4-epidoxorubicin, 4'-Epidoxorubicin, 4-epiadriamycin, 4-epi DXCas No. 56420-45-2

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	-	In Stock
5 mg	$53	-	In Stock
10 mg	$86	-	In Stock
25 mg	$173	-	In Stock
50 mg	$259	-	In Stock
100 mg	$348	-	In Stock
1 mL x 10 mM (in DMSO)	$64	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Appearance:Solid

Color:Red

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Epirubicin (4'-Epidoxorubicin) is an anthracycline antibiotic that acts as a Topoisomerase II inhibitor. It exerts its antitumor effects by intercalating into DNA base pairs, inhibiting DNA replication and transcription, and inducing DNA strand breaks/apoptosis. Epirubicin is widely used in the treatment of breast, gastric, lung, and ovarian cancers.
Targets&IC50	HepG2 cells:1.6 μg/mL
In vitro	In human hepatoma G2 cells, Epirubicin exhibits cytotoxicity (24 h IC50=1.6 μg/mL), induces apoptosis, and upregulates catalase (+50%), GSH-Px (+110%), and SOD (+135–172%) activities [3]. It inhibits DNA/RNA/protein synthesis by complexing with DNA, primarily killing S-phase cells, while high concentrations affect G1/M/G2 phases and membrane integrity [1].
In vivo	In a human breast carcinoma R-27 xenograft model, systemic administration of Epirubicin at a dose of 3.5 mg/kg resulted in a 74.4% reduction in tumor mass. The compound shows broad clinical activity across various malignancies, including malignant lymphomas, lung cancer, and gastrointestinal tumors [4][5].
Synonyms	IMI 28, epi DX, 4-epidoxorubicin, 4'-Epidoxorubicin, 4-epiadriamycin, 4-epi DX

Chemical Properties

Molecular Weight	543.52
Formula	C₂₇H₂₉NO₁₁
Cas No.	56420-45-2
Smiles	OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (183.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8399 mL	9.1993 mL	18.3986 mL	91.9929 mL
5 mM	0.3680 mL	1.8399 mL	3.6797 mL	18.3986 mL
10 mM	0.1840 mL	0.9199 mL	1.8399 mL	9.1993 mL
20 mM	0.0920 mL	0.4600 mL	0.9199 mL	4.5996 mL
50 mM	0.0368 mL	0.1840 mL	0.3680 mL	1.8399 mL
100 mM	0.0184 mL	0.0920 mL	0.1840 mL	0.9199 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Pharmorubicin PFS.IMI-28IMI28EpirubicinepidoxorubicinepidorubicinepiADREPIbrand name: Ellence4-epidoxorubicin HCl