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HOKU-81

Name: HOKU-81
Brand: TargetMol
SKU: T15498
Rating: 4.5 (1 reviews)

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Catalog No. T15498Cas No. 58020-43-2

Alias 4-Hydroxytulobuterol

HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.

HOKU-81

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Catalog No. T15498Alias 4-HydroxytulobuterolCas No. 58020-43-2

HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.

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Product Introduction

Bioactivity

Description	HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.
In vitro	HOKU-81 was approximately 8 times more potent than tulobuterol, approximately twice as potent as salbutamol, and approximately as potent as isoprenaline in relaxing effect on the isolated tracheal smooth muscle preparation of guinea pigs. HOKU-81 appears to be a potent and selective beta 2-stimulant with a slight inotropic action. Adrenergic Receptor Effects of HOKU-81 on isolated trachea and atria of guinea pigs were compared with those of various bronchodilators. This effect of HOKU-81 seems to be due to direct action on the adrenergic beta-receptor.
Synonyms	4-Hydroxytulobuterol

Chemical Properties

Molecular Weight	243.73
Formula	C₁₂H₁₈ClNO₂
Cas No.	58020-43-2
Smiles	CC(C)(C)NCC(O)c1ccc(O)cc1Cl
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (205.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (10.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1029 mL	20.5145 mL	41.0290 mL	205.1450 mL
5 mM	0.8206 mL	4.1029 mL	8.2058 mL	41.0290 mL
10 mM	0.4103 mL	2.0515 mL	4.1029 mL	20.5145 mL
20 mM	0.2051 mL	1.0257 mL	2.0515 mL	10.2573 mL
50 mM	0.0821 mL	0.4103 mL	0.8206 mL	4.1029 mL
100 mM	0.0410 mL	0.2051 mL	0.4103 mL	2.0515 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc