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HOKU-81

🥰Excellent
Catalog No. T15498Cas No. 58020-43-2
Alias 4-Hydroxytulobuterol

HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.

HOKU-81

HOKU-81

🥰Excellent
Catalog No. T15498Alias 4-HydroxytulobuterolCas No. 58020-43-2
HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.
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Product Introduction

Bioactivity
Description
HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.
In vitro
HOKU-81 was approximately 8 times more potent than tulobuterol, approximately twice as potent as salbutamol, and approximately as potent as isoprenaline in relaxing effect on the isolated tracheal smooth muscle preparation of guinea pigs. HOKU-81 appears to be a potent and selective beta 2-stimulant with a slight inotropic action. Adrenergic Receptor Effects of HOKU-81 on isolated trachea and atria of guinea pigs were compared with those of various bronchodilators. This effect of HOKU-81 seems to be due to direct action on the adrenergic beta-receptor.
Synonyms4-Hydroxytulobuterol
Chemical Properties
Molecular Weight243.73
FormulaC12H18ClNO2
Cas No.58020-43-2
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (205.15 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (10.26 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.1029 mL20.5145 mL41.0290 mL205.1450 mL
5 mM0.8206 mL4.1029 mL8.2058 mL41.0290 mL
10 mM0.4103 mL2.0515 mL4.1029 mL20.5145 mL
20 mM0.2051 mL1.0257 mL2.0515 mL10.2573 mL
50 mM0.0821 mL0.4103 mL0.8206 mL4.1029 mL
100 mM0.0410 mL0.2051 mL0.4103 mL2.0515 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

HOKU81HOKU-81HOKU 81
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