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GED-0507-34 Levo
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Catalog No. T202784Cas No. 921195-93-9
Alias Y4H78S56YZ, (S)-3-(4-Aminophenyl)-2-methoxypropanoicacid, (S)-3-(4-Aminophenyl)-2-methoxypropanoic acid
GED-0507-34 Levo ((S)-3-(4-Aminophenyl)-2-methoxypropanoic acid), an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis, decreased the expression of the pro-fibrotic genes Acta2, COL1a1, and Fn1, reduced the protein levels of α-SMA and collagen I-II, the main markers of fibrosis, as well as the major components of the TGFβ/Smad pathway, and decreased the expression of IL-13, CTGF, TGFB and ACTA1, and inhibited TGF-β-induced activation of fibroblasts and IECs cell lines.
GED-0507-34 Levo
😃Good
Purity: 98.19%
Catalog No. T202784Alias Y4H78S56YZ, (S)-3-(4-Aminophenyl)-2-methoxypropanoicacid, (S)-3-(4-Aminophenyl)-2-methoxypropanoic acidCas No. 921195-93-9
GED-0507-34 Levo ((S)-3-(4-Aminophenyl)-2-methoxypropanoic acid), an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis, decreased the expression of the pro-fibrotic genes Acta2, COL1a1, and Fn1, reduced the protein levels of α-SMA and collagen I-II, the main markers of fibrosis, as well as the major components of the TGFβ/Smad pathway, and decreased the expression of IL-13, CTGF, TGFB and ACTA1, and inhibited TGF-β-induced activation of fibroblasts and IECs cell lines.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | In Stock | In Stock | |
| 5 mg | $483 | In Stock | In Stock | |
| 10 mg | $692 | In Stock | In Stock | |
| 25 mg | $1,080 | In Stock | In Stock | |
| 50 mg | $1,490 | In Stock | In Stock | |
| 100 mg | $1,970 | In Stock | In Stock | |
| 200 mg | $2,690 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.19%
Appearance:Solid
Color:Yellow
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Product Introduction
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| Description | GED-0507-34 Levo ((S)-3-(4-Aminophenyl)-2-methoxypropanoic acid), an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis, decreased the expression of the pro-fibrotic genes Acta2, COL1a1, and Fn1, reduced the protein levels of α-SMA and collagen I-II, the main markers of fibrosis, as well as the major components of the TGFβ/Smad pathway, and decreased the expression of IL-13, CTGF, TGFB and ACTA1, and inhibited TGF-β-induced activation of fibroblasts and IECs cell lines. |
| In vitro | GED-0507-34 Levo was added to TGF-β–stimulated intestinal fibroblasts, epithelial cell lines, and primary fibroblasts from ulcerative colitis patients. Expression of α-SMA, Fn1, TGF-β, ACTA1, and epithelial markers was assessed. GED-0507-34 Levo inhibited TGF-β–induced fibrotic activation[1]. |
| In vivo | C57BL/6 mice (n = 110) were administered 2.5% DSS in drinking water (3 cycles over 6 weeks) to induce intestinal fibrosis, and treated daily with GED-0507-34 Levo (30 mg/kg/d; oral). Fibrosis severity was evaluated via macroscopic/histological scores and fibrosis marker expression. GED-0507-34 Levo treatment alleviated intestinal fibrosis[1]. |
| Synonyms | Y4H78S56YZ, (S)-3-(4-Aminophenyl)-2-methoxypropanoicacid, (S)-3-(4-Aminophenyl)-2-methoxypropanoic acid |
| Molecular Weight | 195.22 |
| Formula | C10H13NO3 |
| Cas No. | 921195-93-9 |
| Smiles | C([C@@H](C(O)=O)OC)C1=CC=C(N)C=C1 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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