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GED-0507-34 Levo
🥰Excellent
Catalog No. T202784Cas No. 921195-93-9
Alias Y4H78S56YZ, (S)-3-(4-Aminophenyl)-2-methoxypropanoicacid, (S)-3-(4-Aminophenyl)-2-methoxypropanoic acid
GED-0507-34 Levo ((S)-3-(4-Aminophenyl)-2-methoxypropanoic acid), an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis, decreased the expression of the pro-fibrotic genes Acta2, COL1a1, and Fn1, reduced the protein levels of α-SMA and collagen I-II, the main markers of fibrosis, as well as the major components of the TGFβ/Smad pathway, and decreased the expression of IL-13, CTGF, TGFB and ACTA1, and inhibited TGF-β-induced activation of fibroblasts and IECs cell lines.
GED-0507-34 Levo
🥰Excellent
Purity: 98.19%
Catalog No. T202784Alias Y4H78S56YZ, (S)-3-(4-Aminophenyl)-2-methoxypropanoicacid, (S)-3-(4-Aminophenyl)-2-methoxypropanoic acidCas No. 921195-93-9
GED-0507-34 Levo ((S)-3-(4-Aminophenyl)-2-methoxypropanoic acid), an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis, decreased the expression of the pro-fibrotic genes Acta2, COL1a1, and Fn1, reduced the protein levels of α-SMA and collagen I-II, the main markers of fibrosis, as well as the major components of the TGFβ/Smad pathway, and decreased the expression of IL-13, CTGF, TGFB and ACTA1, and inhibited TGF-β-induced activation of fibroblasts and IECs cell lines.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $483 | In Stock | |
| 10 mg | $692 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,490 | In Stock | |
| 100 mg | $1,970 | In Stock | |
| 200 mg | $2,690 | In Stock |
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Purity:98.19%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | GED-0507-34 Levo ((S)-3-(4-Aminophenyl)-2-methoxypropanoic acid), an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis, decreased the expression of the pro-fibrotic genes Acta2, COL1a1, and Fn1, reduced the protein levels of α-SMA and collagen I-II, the main markers of fibrosis, as well as the major components of the TGFβ/Smad pathway, and decreased the expression of IL-13, CTGF, TGFB and ACTA1, and inhibited TGF-β-induced activation of fibroblasts and IECs cell lines. |
| In vitro | GED-0507-34 Levo was added to TGF-β–stimulated intestinal fibroblasts, epithelial cell lines, and primary fibroblasts from ulcerative colitis patients. Expression of α-SMA, Fn1, TGF-β, ACTA1, and epithelial markers was assessed. GED-0507-34 Levo inhibited TGF-β–induced fibrotic activation[1]. |
| In vivo | C57BL/6 mice (n = 110) were administered 2.5% DSS in drinking water (3 cycles over 6 weeks) to induce intestinal fibrosis, and treated daily with GED-0507-34 Levo (30 mg/kg/d; oral). Fibrosis severity was evaluated via macroscopic/histological scores and fibrosis marker expression. GED-0507-34 Levo treatment alleviated intestinal fibrosis[1]. |
| Alias | Y4H78S56YZ, (S)-3-(4-Aminophenyl)-2-methoxypropanoicacid, (S)-3-(4-Aminophenyl)-2-methoxypropanoic acid |
| Molecular Weight | 195.22 |
| Formula | C10H13NO3 |
| Cas No. | 921195-93-9 |
| Smiles | C([C@@H](C(O)=O)OC)C1=CC=C(N)C=C1 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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