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Premarin

Name: Premarin
Brand: TargetMol
SKU: T36857L
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36857LCas No. 481-97-0

Alias Estrone sulfate, Estrone 3-sulfate

Premarin (Estrone 3-sulfate) is an an estrogen sulfate with neuroprotective actions during traumatic brain injury.

Premarin

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Purity: 99.74%

Catalog No. T36857LAlias Estrone sulfate, Estrone 3-sulfateCas No. 481-97-0

Premarin (Estrone 3-sulfate) is an an estrogen sulfate with neuroprotective actions during traumatic brain injury.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$195	In Stock	In Stock
5 mg	$437	In Stock	In Stock
10 mg	$646	In Stock	In Stock
25 mg	$987	In Stock	In Stock
50 mg	$1,380	-	In Stock
100 mg	$1,860	-	In Stock
1 mL x 10 mM (in DMSO)	$458	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.74%

Appearance:Solid

Color:White

Resource Download

COA LCMS HRMS MS HNMR

Product Introduction

Bioactivity

Description	Premarin (Estrone 3-sulfate) is an an estrogen sulfate with neuroprotective actions during traumatic brain injury.
In vivo	In estrogen receptor-alpha blockade rats, Premarin therapy had less or no effect on fluid percussion injury-induced behavioral deficits, cerebral infarction and apoptosis, and activated inflammation. Premarin-induced angiogenesis and neurogenesis were estrogen receptor-alpha blockade-reduced[1].
Synonyms	Estrone sulfate, Estrone 3-sulfate

Chemical Properties

Molecular Weight	350.43
Formula	C₁₈H₂₂O₅S
Cas No.	481-97-0
Smiles	C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OS(=O)(=O)O)=CC4)(CC1)[H])[H])(CCC2=O)[H]
Relative Density.	1.349 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (142.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8536 mL	14.2682 mL	28.5364 mL	142.6818 mL
5 mM	0.5707 mL	2.8536 mL	5.7073 mL	28.5364 mL
10 mM	0.2854 mL	1.4268 mL	2.8536 mL	14.2682 mL
20 mM	0.1427 mL	0.7134 mL	1.4268 mL	7.1341 mL
50 mM	0.0571 mL	0.2854 mL	0.5707 mL	2.8536 mL
100 mM	0.0285 mL	0.1427 mL	0.2854 mL	1.4268 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc