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NLS-CPP

Name: NLS-CPP
Brand: TargetMol
SKU: TP3775
Rating: 4.5 (1 reviews)

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Catalog No. TP3775Cas No. 1228086-59-6

Alias NLS-cell penetrating peptide

NLS-CPP is a nuclear localization signal (NLS)-cell penetrating peptide that includes the NLS from OCT6. It facilitates nuclear delivery and can be utilized in the study of chronic inflammatory diseases, including metabolic dysfunction-associated steatohepatitis (MASH) and osteoarthritis (OA).

NLS-CPP

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Catalog No. TP3775Alias NLS-cell penetrating peptideCas No. 1228086-59-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	NLS-CPP is a nuclear localization signal (NLS)-cell penetrating peptide that includes the NLS from OCT6. It facilitates nuclear delivery and can be utilized in the study of chronic inflammatory diseases, including metabolic dysfunction-associated steatohepatitis (MASH) and osteoarthritis (OA).
Synonyms	NLS-cell penetrating peptide

Chemical Properties

Molecular Weight	1558.74
Formula	C₆₃H₁₁₅N₂₅O₂₁
Cas No.	1228086-59-6
Smiles	[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)(NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)N)=O)CCC(O)=O)=O)CCC(O)=O)=O)C)=O)C)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCNC(=N)N
Sequence	Glu-Glu-Glu-Ala-Ala-Gly-Arg-Lys-Arg-Lys-Lys-Arg-Thr
Sequence Short	EEEAAGRKRKKRT

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc