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Cyanostatin B
Catalog No. TP4044 Copy Product Info
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Cyanostatin B, a lipopeptide derived from cyanobacteria, acts as a leucine aminopeptidase (LAP) inhibitor with an IC50 of 12 ng/mL. It exhibits weak inhibitory effects on protein phosphatase (PP2A) and angiotensin-converting enzyme (ACE), with an IC50 of 130 μg/mL. While Cyanostatin B shows no toxicity to brine shrimp, it demonstrates cytotoxicity and genotoxicity in human liver cells in vitro. Furthermore, Cyanostatin B inhibits the proliferation of HepG cells, induces DNA single-strand breaks, and causes genomic instability.
Cyanostatin B
Copy Product Info🥰Excellent
Catalog No. TP4044
Cyanostatin B, a lipopeptide derived from cyanobacteria, acts as a leucine aminopeptidase (LAP) inhibitor with an IC50 of 12 ng/mL. It exhibits weak inhibitory effects on protein phosphatase (PP2A) and angiotensin-converting enzyme (ACE), with an IC50 of 130 μg/mL. While Cyanostatin B shows no toxicity to brine shrimp, it demonstrates cytotoxicity and genotoxicity in human liver cells in vitro. Furthermore, Cyanostatin B inhibits the proliferation of HepG cells, induces DNA single-strand breaks, and causes genomic instability.
Cyanostatin B
Cas No. 850131-23-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cyanostatin B, a lipopeptide derived from cyanobacteria, acts as a leucine aminopeptidase (LAP) inhibitor with an IC50 of 12 ng/mL. It exhibits weak inhibitory effects on protein phosphatase (PP2A) and angiotensin-converting enzyme (ACE), with an IC50 of 130 μg/mL. While Cyanostatin B shows no toxicity to brine shrimp, it demonstrates cytotoxicity and genotoxicity in human liver cells in vitro. Furthermore, Cyanostatin B inhibits the proliferation of HepG cells, induces DNA single-strand breaks, and causes genomic instability. |
| In vitro | Cyanostatin B exhibits no toxicity to brine shrimp larvae (nauplii) at concentrations of 0-75 μg/mL over 24 hours. When HepG2 cells are exposed to 0-10 μg/mL for 24-48 hours, Cyanostatin B shows concentration-dependent inhibition of cell proliferation after 72 hours. At concentrations of 0-1 μg/mL over 24-48 hours, it induces DNA single-strand breaks (SSB) but not DNA double-strand breaks (DSB) in HepG2 cells. At 1 μg/mL for 24-72 hours, Cyanostatin B causes chromosomal breakage, resulting in chromosome breakage or complete chromosome loss in HepG2 cells. |
| Molecular Weight | 753.94 |
| Formula | C40H59N5O9 |
| Cas No. | 850131-23-6 |
| Smiles | C([C@@H](N(C([C@H](CC1=CC=C(O)C=C1)NC([C@H]([C@@H](CCCCCCC)N)O)=O)=O)C)[C@H](CC)C)(=O)N2[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(O)=O)=O)CCC2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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