Heveadride is a fungal metabolite and antifungal agonist with activity against filamentous fungi and certain human pathogenic yeasts. It downregulates TNFα-induced NF-κB activity in human chronic leukemia cells, with an IC50 value of 82.7 μM.

Heveadride (Compound 2) exhibits moderate antifungal activity against filamentous fungi at concentrations of 5 and 10 μg/disc, shows no activity against yeast at 5 μg/disc, and demonstrates weak activity against some yeast strains at 100 μg/disc. Heveadride (Compound 4), at concentrations ranging from 10-100 μM over 2 hours, displays dose-dependent inhibition of TNFα-induced NF-κB activity in K562 cells. Heveadride, at concentrations of 0.1-100 μM for durations of 8-72 hours, does not significantly reduce K562 cell viability at any concentration or time point, but inhibits proliferation of K562 cells at 100 μM.