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B022

Name: B022
Brand: TargetMol
SKU: T14491
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14491 Copy Product Info

Purity: 99.55%

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B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM) and a chemical probe for treating liver inflammation and injury, protecting the liver from inflammation and injury caused by oxidative stress and toxins.

Cas No. 1202764-53-1

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Pack Size	Price	USA Stock	Global Stock
1 mg	$68	In Stock	In Stock
5 mg	$168	In Stock	In Stock
10 mg	$247	In Stock	In Stock
25 mg	$418	In Stock	In Stock
50 mg	$612	In Stock	In Stock
100 mg	$786	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.55%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM) and a chemical probe for treating liver inflammation and injury, protecting the liver from inflammation and injury caused by oxidative stress and toxins.
Targets & IC50	NF-κB-inducing kinase (NIK):4.2 nM (Ki)
In vitro	B022 treatment of Hepa1 cells (0 μM, 0.5 μM, 5 μM; 12 hours) can suppress NIK-induced p52 formation in a dose-dependent manner[1].
In vivo	In STOP-NIK male mice (8 weeks old) infected with Ad-cre, B022 (30 mg/kg; intravenous injection; twice daily; for 10 days) completely prevents the lethal effects induced by abnormally high levels of hepatic NIK in mice. It inhibits the majority of the deteriorating effects caused by aberrant activation of hepatic NIK[1].

Chemical Properties

Molecular Weight	397.88
Formula	C₁₉H₁₆ClN₅OS
Cas No.	1202764-53-1
Smiles	CC(O)(C#Cc1ccc2CCN(c2c1)c1nc(N)ncc1Cl)c1nccs1
Relative Density.	1.53 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (377 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: < 10 mg/mL (25.13 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (25.13 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5133 mL	12.5666 mL	25.1332 mL	125.6660 mL
5 mM	0.5027 mL	2.5133 mL	5.0266 mL	25.1332 mL
10 mM	0.2513 mL	1.2567 mL	2.5133 mL	12.5666 mL
20 mM	0.1257 mL	0.6283 mL	1.2567 mL	6.2833 mL
50 mM	0.0503 mL	0.2513 mL	0.5027 mL	2.5133 mL
100 mM	0.0251 mL	0.1257 mL	0.2513 mL	1.2567 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc