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RA375

RA375
RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy against cancer lines compared to RA190, RA375 owes its increased activity to nitro ring substituents and the inclusion of a chloroacetamide warhead.
Catalog No. T36902Cas No. 2649154-57-2
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Purity:99.35%
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RA375

Catalog No. T36902Cas No. 2649154-57-2
RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy against cancer lines compared to RA190, RA375 owes its increased activity to nitro ring substituents and the inclusion of a chloroacetamide warhead.
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Pack SizePriceAvailabilityQuantity
1 mg$35In Stock
5 mg$88In Stock
10 mg$148In Stock
25 mg$250In Stock
50 mg$357In Stock
100 mg$517In Stock
1 mL x 10 mM (in DMSO)$118In Stock
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Product Introduction

Bioactivity
Description
RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy against cancer lines compared to RA190, RA375 owes its increased activity to nitro ring substituents and the inclusion of a chloroacetamide warhead.
In vivo
RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice[1].
AliasRA375
Chemical Properties
Molecular Weight588.99
FormulaC30H25ClN4O7
Cas No.2649154-57-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 125 mg/mL (212.22 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6978 mL8.4891 mL16.9782 mL84.8911 mL
5 mM0.3396 mL1.6978 mL3.3956 mL16.9782 mL
10 mM0.1698 mL0.8489 mL1.6978 mL8.4891 mL
20 mM0.0849 mL0.4245 mL0.8489 mL4.2446 mL
50 mM0.0340 mL0.1698 mL0.3396 mL1.6978 mL
100 mM0.0170 mL0.0849 mL0.1698 mL0.8489 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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