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Dehydrocrenatidine

Name: Dehydrocrenatidine
Brand: TargetMol
SKU: T19934
Rating: 4.5 (1 reviews)

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Catalog No. T19934Cas No. 65236-62-6

Alias TOP-3, TOP3, TOP 3, O-Methylpicrasidine I, Kumujian G

Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis.

Dehydrocrenatidine

😃Good

Catalog No. T19934Alias TOP-3, TOP3, TOP 3, O-Methylpicrasidine I, Kumujian GCas No. 65236-62-6

Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis.

Pack Size	Price	Availability	Quantity
100 mg	$13,230	10-14 weeks

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Product Introduction

Bioactivity

Description	Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis.
In vitro	In DU145 and MDA-MB-468 cells, Dehydrocrenatidine inhibits cell survival and induces cell apoptosis in a JAK-STAT3-dependent manner. Dehydrocrenatidine reduces the STAT3 phosphorylation stimulated by IL-6, IFN-α, and IFN-γ[1]. Dehydrocrenatidine reduces tetrodotoxin-resistant and sensitive voltage-gated sodium channel currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2].
In vivo	Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[2].
Synonyms	TOP-3, TOP3, TOP 3, O-Methylpicrasidine I, Kumujian G

Chemical Properties

Molecular Weight	254.28
Formula	C₁₅H₁₄N₂O₂
Cas No.	65236-62-6
Smiles	O(C)C1=C2C=3C(NC2=C(C=C)N=C1)=C(OC)C=CC3
Relative Density.	1.251 g/cm3

Storage & Solubility Information

Storage	store at low temperature,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: Soluble

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