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SNX3-IN-1
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Catalog No. T219219 Copy Product Info
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SNX3-IN-1 is an inhibitor of sorting nexin 3 (SNX3). It reduces SNX3 protein expression and suppresses the activation of the SNX3-mediated Wnt/β-catenin signaling pathway. SNX3-IN-1 inhibits the proliferation and migration of cells associated with pulmonary fibrosis and reduces the expression of fibrosis markers α-SMA and COL-1. SNX3-IN-1 is applicable in pulmonary fibrosis research.
SNX3-IN-1
Cas No. 2344793-72-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SNX3-IN-1 is an inhibitor of sorting nexin 3 (SNX3). It reduces SNX3 protein expression and suppresses the activation of the SNX3-mediated Wnt/β-catenin signaling pathway. SNX3-IN-1 inhibits the proliferation and migration of cells associated with pulmonary fibrosis and reduces the expression of fibrosis markers α-SMA and COL-1. SNX3-IN-1 is applicable in pulmonary fibrosis research. |
| In vitro | SNX3-IN-1 (Compound LC4) inhibits the enhanced migration capability of fibroblasts overexpressing SNX3. It also suppresses β-catenin accumulation and nuclear localization induced by SNX3 in cells. At a concentration of 10 μM, SNX3-IN-1 inhibits TGF-β1-induced α-SMA expression in both AT2 cells and fibroblasts, thereby reducing fibrotic activation. |
| In vivo | SNX3-IN-1 (Compound LC4), administered at 10 mg/kg via intratracheal delivery once a week for three weeks, effectively ameliorates Wnt/β-catenin pathway activation, lung function impairment, and fibrosis in a mouse model of pulmonary fibrosis. |
| Molecular Weight | 396.43 |
| Formula | C23H24O6 |
| Cas No. | 2344793-72-0 |
| Smiles | O=C(O)C(OC=1C(=CC(C=C2OC3=CC(OCC)=CC=C3C2=O)=CC1C)C)(C)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: SNX3-IN-1 in vivo | SNX3-IN-1 in vitro | SNX3-IN-1 formula | SNX3-IN-1 molecular weight
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