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L-DABA hydrobromide

Catalog No. T77795 CAS 73143-97-2

Synonyms: L-2,4-Diaminobutyric acid hydrobromide

L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) is a potent GABA transaminase inhibitor with antitumor and anticonvulsant activity for the study of neurological disorders.

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L-DABA hydrobromide, CAS 73143-97-2

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100 mg	In stock	$ 41.00

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Purity: 99.11%

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Description	L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) is a potent GABA transaminase inhibitor with antitumor and anticonvulsant activity for the study of neurological disorders.
In vitro	Incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C irreversibly and completely damages tumor cells. The cell-destructive effect caused by L-DABA hydrobromide is likely a result of osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA hydrobromide. Concomitant incubation with L-alanine and L-methionine can abolish the harmful effect of L-DABA hydrobromide[1]. Kinetic studies indicate that L-DABA hydrobromide is a non-linear, non-competitive inhibitor of GABA transaminase activity. The elevation of GABA levels induced by L-DABA hydrobromide parallels the inhibition of GABA transaminase activity[2]. L-2,4-Diaminobutyric acid, an amino acid analogue, produces a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA hydrobromide necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line[2].
In vivo	Treatment with L-DABA hydrobromide results in a 43.4% reduction of tumor growth[1]. In vivo, L-DABA hydrobromide is a more effective inhibitor of GABA transaminase compared to its efficacy in vitro[3].

Synonyms	L-2,4-Diaminobutyric acid hydrobromide
Molecular Weight	199.05
Formula	C4H11BrN2O2
CAS No.	73143-97-2

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1.99 mg/mL (10 mM), Sonication is recommended.

References and Literature

1. Ronquist G, et al. Antitumor activity of L-2,4 diaminobuturic acid against mouse fibrosarcoma cells in vitro and in vivo. J Cancer Res Clin Oncol. 1980;96(3):259-68. 2. Panasci L, et al. The cytolytic effect of L-2,4 diaminobutyric acid with malignant glioma cells and fibroblasts. Cancer Chemother Pharmacol. 1988;21(2):143-4. 3. Beart PM, et al. l-2,4-Diaminobutyric acid and the GABA system. Neurosci Lett. 1977 Jul;5(3-4):193-8.

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Keywords

L-DABA hydrobromide 73143-97-2 Metabolism Others Endogenous Metabolite L-2,4-Diaminobutyric acid Hydrobromide L-DABA Hydrobromide L-2,4-Diaminobutyric acid hydrobromide inhibitor inhibit

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