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5-LOX-IN-2

Name: 5-LOX-IN-2
Brand: TargetMol
SKU: T77528
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77528Cas No. 179691-97-5

5-LOx-in-2 is a 5-lipoxygenase inhibitor (5-LOX) with an IC50 value of 0.33 μM. 5-lox-in-2 inhibits 5-LOX action IN a dose-dependent manner. 5-LOX-IN-2 can reduce the cell activity of kidney cancer cells and induce apoptosis, and can be used in cancer research.

5-LOX-IN-2

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Purity: 98.74%

Catalog No. T77528Cas No. 179691-97-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	-	In Stock
5 mg	$88	-	In Stock
10 mg	$145	-	In Stock
25 mg	$308	-	In Stock
50 mg	$437	-	In Stock
100 mg	$591	-	In Stock
200 mg	$810	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.74%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	5-LOx-in-2 is a 5-lipoxygenase inhibitor (5-LOX) with an IC50 value of 0.33 μM. 5-lox-in-2 inhibits 5-LOX action IN a dose-dependent manner. 5-LOX-IN-2 can reduce the cell activity of kidney cancer cells and induce apoptosis, and can be used in cancer research.
Targets&IC50	5-LOX:0.33 μM
In vitro	5-LOX-IN-2 at a concentration of 0-100 μM, after 4 days of action, reduced the activity of renal cancer cells (RCC4, RCC10, 786.0 cells) and showed higher selectivity for RCC4 and 786.0 cells deficient in the von Hippel-Lindau (VHL) tumor suppressor gene. 5-LOX-IN-2 at a concentration of 0-10 μM, after 24 hours of action, was capable of increasing the expression of LC3B and p62, and inducing apoptosis through the activation of the caspase-3 pathway. concentration and after 24 hours of action, it was able to increase the expression of LC3B and p62, block the autophagic flow in RCC4 cells, and induce apoptosis by activating the caspase-3 pathway.

Chemical Properties

Molecular Weight	284.31
Formula	C₁₇H₁₆O₄
Cas No.	179691-97-5
Smiles	C(=C/C(OCCC1=CC=CC=C1)=O)\C2=C(O)C=CC(O)=C2
Relative Density.	1.266 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (175.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5173 mL	17.5864 mL	35.1729 mL	175.8644 mL
5 mM	0.7035 mL	3.5173 mL	7.0346 mL	35.1729 mL
10 mM	0.3517 mL	1.7586 mL	3.5173 mL	17.5864 mL
20 mM	0.1759 mL	0.8793 mL	1.7586 mL	8.7932 mL
50 mM	0.0703 mL	0.3517 mL	0.7035 mL	3.5173 mL
100 mM	0.0352 mL	0.1759 mL	0.3517 mL	1.7586 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc