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AC-186

Name: AC-186
Brand: TargetMol
SKU: T26537
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26537Cas No. 1421854-16-1

Alias AC186, AC 186

AC-186 is a nonsteroidal estrogen receptor β (ERβ) agonist with different affinities for ERβ and ERα, with an EC50 of 6 nM for ERβ and 5000 nM for ERα. AC-186 has neuroprotective activity and has been used in the study of Parkinson's disease.

AC-186

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Purity: 99.53%

Catalog No. T26537Alias AC186, AC 186Cas No. 1421854-16-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$106	In Stock	In Stock
10 mg	$159	In Stock	In Stock
25 mg	$289	In Stock	In Stock
50 mg	$438	In Stock	In Stock
100 mg	$658	-	In Stock
200 mg	$919	-	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.53%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	AC-186 is a nonsteroidal estrogen receptor β (ERβ) agonist with different affinities for ERβ and ERα, with an EC50 of 6 nM for ERβ and 5000 nM for ERα. AC-186 has neuroprotective activity and has been used in the study of Parkinson's disease.
Targets&IC50	ERα:5000 nM (EC50), ERβ:6 nM (EC50)
In vitro	In LNCaP cells, AC-186 (10 μM; 72 hours) inhibits the growth of LNCaP cells[1].
In vivo	In male Sprague-Dawley rats weighing 225-250 g, AC-186 (10 mg/kg; s.c.; once) prevented motor, cognitive, and sensorimotor gating deficits and mitigated the loss of dopamine neurons in the substantia nigra, but had no effect in females[1].
Synonyms	AC186, AC 186

Chemical Properties

Molecular Weight	306.32
Formula	C₁₈H₁₇F₃O
Cas No.	1421854-16-1
Smiles	FC=1C=CC=CC1C2(C3=CC=C(O)C=C3)CCC(F)(F)CC2
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (261.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2646 mL	16.3228 mL	32.6456 mL	163.2280 mL
5 mM	0.6529 mL	3.2646 mL	6.5291 mL	32.6456 mL
10 mM	0.3265 mL	1.6323 mL	3.2646 mL	16.3228 mL
20 mM	0.1632 mL	0.8161 mL	1.6323 mL	8.1614 mL
50 mM	0.0653 mL	0.3265 mL	0.6529 mL	3.2646 mL
100 mM	0.0326 mL	0.1632 mL	0.3265 mL	1.6323 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc