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hMAO-B-IN-32 (Synonyms: Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate)

Name: hMAO-B-IN-32
Brand: TargetMol
SKU: T78232
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T78232 Copy Product Info

Purity: 99.97%

🥰Excellent

hMAO-B-IN-32 is a potent hMAO-B selective inhibitor with an IC50 of 45.52 μM.

hMAO-B-IN-32

Copy Product Info

🥰Excellent

Catalog No. T78232

Synonyms Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate

hMAO-B-IN-32 is a potent hMAO-B selective inhibitor with an IC50 of 45.52 μM.

Cas No. 28705-46-6

Pack Size	Price	USA Stock	Global Stock	Quantity
1 g	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

hMAO-B-IN-32 AI Summary

hMAO-B-IN-32 shows no significant cytotoxicity against human OVCAR5 and LOXIMVI cells after 96 hours, with IC50 values above 10000.0 nM. It exhibits a minimal effect on calf thymus DNA binding affinity, indicated by a small change in thermal denaturation temperature (ΔTm = 0.2 degrees Celsius) at a concentration of 20 µM over different time points (4, 18, and 72 hours). Additionally, hMAO-B-IN-32 inhibits human recombinant monoamine oxidase-B (MAO-B) with an IC50 value of 45520.0 nM and has a selectivity ratio of the IC50 for human recombinant MAO-A to IC50 for human recombinant MAO-B greater than 2.2..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	hMAO-B-IN-32 is a potent hMAO-B selective inhibitor with an IC50 of 45.52 μM.
Synonyms	Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate

Chemical Properties

Molecular Weight	289.33
Formula	C₁₆H₁₉NO₄
Cas No.	28705-46-6
Smiles	CCOC(=O)c1cc2ccc(cc2oc1=O)N(CC)CC

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (172.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4563 mL	17.2813 mL	34.5626 mL	172.8131 mL
5 mM	0.6913 mL	3.4563 mL	6.9125 mL	34.5626 mL
10 mM	0.3456 mL	1.7281 mL	3.4563 mL	17.2813 mL
20 mM	0.1728 mL	0.8641 mL	1.7281 mL	8.6407 mL
50 mM	0.0691 mL	0.3456 mL	0.6913 mL	3.4563 mL
100 mM	0.0346 mL	0.1728 mL	0.3456 mL	1.7281 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc