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SARS-CoV-2 Guanine-N7 methyltransferase Protein (His)
(Synonyms: SARS-CoV 2 nsp14, SARS-CoV 2 ExoN, Guanine-N7 methyltransferase) Copy Product InfoSynonyms: SARS-CoV 2 nsp14, SARS-CoV 2 ExoN, Guanine-N7 methyltransferase
Catalog No. TMPJ-01429 Copy Product Info
The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $112 | 7-10 days | 7-10 days | |
| 10 μg | $183 | 7-10 days | 7-10 days | |
| 20 μg | $295 | 7-10 days | 7-10 days | |
| 50 μg | $558 | 7-10 days | 7-10 days | |
| 100 μg | $919 | 7-10 days | 7-10 days | |
| 200 μg | $1,520 | 7-10 days | 7-10 days | |
| 500 μg | $2,970 | 7-10 days | 7-10 days | |
| 1 mg | $4,480 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14. |
| Species | SARS-CoV-2 |
| Expression System | E. coli |
| Tag | N-6xHis |
| Accession Number | YP_009725309.1 |
| Amino Acid | Ala1-Gln527 |
| Construction | Ala1-Gln527 |
| Formulation | Supplied as a 0.2 μm filtered solution of 20 mM PB, 100 mM NaCl, 2 mM DTT, 20% Glycerol, 0.1% TritonX-100, pH 6.0. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Proteins are shipped with blue ice. |
| Synonyms | SARS-CoV 2 nsp14, SARS-CoV 2 ExoN, Guanine-N7 methyltransferase |
| Research Background |
| Molecular Weight | 60 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: SARS-CoV-2 Guanine-N7 methyltransferase Protein (His) chemical structure | SARS-CoV-2 Guanine-N7 methyltransferase Protein (His) molecular weight
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