SARS-CoV-2 Guanine-N7 methyltransferase Protein (His)

Name: SARS-CoV-2 Guanine-N7 methyltransferase Protein (His)
Brand: TargetMol
SKU: TMPJ-01429
Rating: 4.5 (1 reviews)

(Synonyms: SARS-CoV 2 nsp14, SARS-CoV 2 ExoN, Guanine-N7 methyltransferase) Copy Product Info

Synonyms: SARS-CoV 2 nsp14, SARS-CoV 2 ExoN, Guanine-N7 methyltransferase

Catalog No. TMPJ-01429 Copy Product Info

The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.

SARS-CoV-2 Guanine-N7 methyltransferase Protein (His)

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Pack Size	Price	USA Stock	Global Stock
10 µg	$183	7-10 days	7-10 days
20 µg	$295	7-10 days	7-10 days
50 µg	$558	7-10 days	7-10 days
100 µg	$919	7-10 days	7-10 days
200 µg	$1,520	7-10 days	7-10 days
500 µg	$2,970	7-10 days	7-10 days
1 mg	$4,480	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.
Species	SARS-CoV-2
Expression System	E. coli
Tag	N-6xHis
Accession Number	YP_009725309.1
Amino Acid	Ala1-Gln527
Construction	Ala1-Gln527
Formulation	Supplied as a 0.2 μm filtered solution of 20 mM PB, 100 mM NaCl, 2 mM DTT, 20% Glycerol, 0.1% TritonX-100, pH 6.0.
Synonyms	SARS-CoV 2 nsp14, SARS-CoV 2 ExoN, Guanine-N7 methyltransferase
Research Background	The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14.

Chemical Properties

Molecular Weight

60 KDa (reducing condition)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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