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Cathelicidin-2 (128-153) (chicken) TFA

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Catalog No. T83698
Alias Myeloid Antimicrobial Peptide 27 (128-153), Fowlicidin-2 (128-153), CATH-2 (128-153)

Cathelicidin-2 (CATH-2) (128-153) is a synthetic antimicrobial peptide derived from amino acids 128-153 of chicken CATH-2, demonstrating activity against pathogens such as E. coli, S. aureus, S. enteritidis, and B. globigii in a dose-dependent manner. At a concentration of 40 µM, it induces hemolysis in chicken erythrocytes without exhibiting cytotoxicity towards human peripheral blood mononuclear cells (PBMCs). Additionally, it stimulates the production of the chemokine CCL2 and suppresses LPS-induced secretion of TNF-α, IL-6, IL-8, and IL-10 in human PBMCs.

Cathelicidin-2 (128-153) (chicken) TFA

Cathelicidin-2 (128-153) (chicken) TFA

😃Good
Catalog No. T83698Alias Myeloid Antimicrobial Peptide 27 (128-153), Fowlicidin-2 (128-153), CATH-2 (128-153)
Cathelicidin-2 (CATH-2) (128-153) is a synthetic antimicrobial peptide derived from amino acids 128-153 of chicken CATH-2, demonstrating activity against pathogens such as E. coli, S. aureus, S. enteritidis, and B. globigii in a dose-dependent manner. At a concentration of 40 µM, it induces hemolysis in chicken erythrocytes without exhibiting cytotoxicity towards human peripheral blood mononuclear cells (PBMCs). Additionally, it stimulates the production of the chemokine CCL2 and suppresses LPS-induced secretion of TNF-α, IL-6, IL-8, and IL-10 in human PBMCs.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$95InquiryInquiry
10 mg$756InquiryInquiry
25 mg$1,650InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Bioactivity
Description
Cathelicidin-2 (CATH-2) (128-153) is a synthetic antimicrobial peptide derived from amino acids 128-153 of chicken CATH-2, demonstrating activity against pathogens such as E. coli, S. aureus, S. enteritidis, and B. globigii in a dose-dependent manner. At a concentration of 40 µM, it induces hemolysis in chicken erythrocytes without exhibiting cytotoxicity towards human peripheral blood mononuclear cells (PBMCs). Additionally, it stimulates the production of the chemokine CCL2 and suppresses LPS-induced secretion of TNF-α, IL-6, IL-8, and IL-10 in human PBMCs.
SynonymsMyeloid Antimicrobial Peptide 27 (128-153), Fowlicidin-2 (128-153), CATH-2 (128-153)
Chemical Properties
Molecular Weight3206.90
FormulaC147H245N51O30.XCF3COOH
Smiles[H]NCCCC[C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](NC([C@H](CCCNC(N)=N)N[H])=O)CC1=CC=CC=C1)=O)=O)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)=O)C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N3CCC[C@H]3C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@@]([H])([C@@H](C)O)C(N[C@@](C(N[C@@]([H])([C@@H](C)O)C(N[C@@](C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)=O)C)=O)=O)=O)=O)([H])[C@H](CC)C)=O)=O)([H])[C@H](CC)C)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)([H])[C@H](CC)C)=O.OC(C(F)(F)F)=O
SequenceH-Arg-Phe-Gly-Arg-Phe-Leu-Arg-Lys-Ile-Arg-Arg-Phe-Arg-Pro-Lys-Val-Thr-Ile-Thr-Ile-Gln-Gly-Ser-Ala-Arg-Phe-NH2
Sequence ShortRFGRFLRKIRRFRPKVTITIQGSARF
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: Soluble

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TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
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Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

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