Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HG106, which is anti-inflammatory and may be used to treat the growth of diseases such as malignant tumours caused by mutations in the RAS gene., which is anti-inflammatory and may be used to treat the growth of diseases such as malignant tumours caused by mutations in the RAS gene.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 58.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 239.00 | |
25 mg | In stock | $ 455.00 | |
50 mg | In stock | $ 657.00 | |
100 mg | In stock | $ 918.00 | |
500 mg | In stock | $ 1,830.00 |
Description | HG106, which is anti-inflammatory and may be used to treat the growth of diseases such as malignant tumours caused by mutations in the RAS gene., which is anti-inflammatory and may be used to treat the growth of diseases such as malignant tumours caused by mutations in the RAS gene. |
In vitro | We identified a potent SLC7A11 inhibitor, HG106, that markedly decreased cystine uptake and intracellular glutathione biosynthesis. Furthermore, HG106 exhibited selective cytotoxicity toward KRAS-mutant cells by increasing oxidative stress- and ER stress-mediated cell apoptosis. [1] |
In vivo | Treatment of KRAS-mutant LUAD with HG106 in several preclinical lung cancer mouse models led to marked tumor suppression and prolonged survival. [1] |
Molecular Weight | 316.74 |
Formula | C15H13ClN4O2 |
CAS No. | 928712-10-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
Ethanol: Insoluble
DMSO: 18.9 mg/mL (59.7 mM)
You can also refer to dose conversion for different animals. More
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HG106 928712-10-1 Others Acetamide,2chloroN[2(4methoxyphenyl)2Hbenzotriazol5yl] HG-106 HG 106 inhibitor inhibit