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ADP-β-S trilithium

Name: ADP-β-S trilithium
Brand: TargetMol
SKU: T206052
Rating: 4.5 (1 reviews)

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Catalog No. T206052Cas No. 73536-95-5

Alias Adenosine 5'-β-thiodiphosphate (trilithium)

ADP-β-S trilithium is an ADP analog and P2Y12 receptor activator that upregulates IL-1β and IL-6 in microglia, promoting NLRP3 activation along with NF-κB phosphorylation and nuclear translocation.

ADP-β-S trilithium

🥰Excellent

Catalog No. T206052Alias Adenosine 5'-β-thiodiphosphate (trilithium)Cas No. 73536-95-5

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Product Introduction

Bioactivity

Description	ADP-β-S trilithium is an ADP analog and P2Y12 receptor activator that upregulates IL-1β and IL-6 in microglia, promoting NLRP3 activation along with NF-κB phosphorylation and nuclear translocation.
Synonyms	Adenosine 5'-β-thiodiphosphate (trilithium)

Chemical Properties

Molecular Weight	461.07
Formula	C₁₀H₁₂Li₃N₅O₉P₂S
Cas No.	73536-95-5
Smiles	O[C@H]1[C@@H](O[C@@H]([C@H]1[O-])COP(OP([O-])(S)=O)([O-])=O)N2C3=NC=NC(N)=C3N=C2.[Li+].[Li+].[Li+]
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 16.00 mg/mL (34.70 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.1689 mL	10.8443 mL	21.6887 mL	108.4434 mL
5 mM	0.4338 mL	2.1689 mL	4.3377 mL	21.6887 mL
10 mM	0.2169 mL	1.0844 mL	2.1689 mL	10.8443 mL
20 mM	0.1084 mL	0.5422 mL	1.0844 mL	5.4222 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc