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Triflupromazine hydrochloride

Name: Triflupromazine hydrochloride
Brand: TargetMol
SKU: T0302
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0302Cas No. 1098-60-8

Alias Neoprin, Fluorofen, Fluopromazine hydrochloride, Flumazin

Triflupromazine hydrochloride (Fluopromazine hydrochloride), an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.

Triflupromazine hydrochloride

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Purity: 99.82%

Catalog No. T0302Alias Neoprin, Fluorofen, Fluopromazine hydrochloride, FlumazinCas No. 1098-60-8

Triflupromazine hydrochloride (Fluopromazine hydrochloride), an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	In Stock	In Stock
200 mg	$50	In Stock	In Stock
500 mg	$82	In Stock	In Stock
1 g	$118	In Stock	In Stock
2 g	$177	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Color:White

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COA HNMR LCMS

Product Introduction

Triflupromazine hydrochloride AI Summary

Triflupromazine hydrochloride exhibits antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 6309.57 nM to 12589.25 nM after 72 hours of testing using the SYBR green assay, indicating moderate to potent inhibition of the parasite's growth. Additionally, the compound demonstrates significant inhibitory activity on OATP1B1 and OATP1B3 transporters in CHO cells, showing inhibition rates of 185.58% and 83.79% respectively at a 10 uM concentration using the sodium fluorescein uptake assay. Triflupromazine hydrochloride also shows antiviral activity, as evidenced by a 44.25% inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a 10 uM concentration after 48 hours. However, in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), it displayed a low inhibition of cell viability with an inhibition index of -0.1177 and a similar low inhibition of -0.07% in VERO-6 cells at the same concentration and exposure conditions. The compound's inhibition of SARS-CoV-2 3CL-Pro protease was determined to be -5.673% at a 20 µM concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Triflupromazine hydrochloride (Fluopromazine hydrochloride), an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.
Synonyms	Neoprin, Fluorofen, Fluopromazine hydrochloride, Flumazin

Chemical Properties

Molecular Weight	388.88
Formula	C₁₈H₂₀ClF₃N₂S
Cas No.	1098-60-8
Smiles	Cl.CN(C)CCCN1c2ccccc2Sc2ccc(cc12)C(F)(F)F
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (128.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5715 mL	12.8574 mL	25.7149 mL	128.5744 mL
5 mM	0.5143 mL	2.5715 mL	5.1430 mL	25.7149 mL
10 mM	0.2571 mL	1.2857 mL	2.5715 mL	12.8574 mL
20 mM	0.1286 mL	0.6429 mL	1.2857 mL	6.4287 mL
50 mM	0.0514 mL	0.2571 mL	0.5143 mL	2.5715 mL
100 mM	0.0257 mL	0.1286 mL	0.2571 mL	1.2857 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc