Guanylin(human)

Name: Guanylin(human)
Brand: TargetMol
SKU: TP2034
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Catalog No. TP2034Cas No. 183200-12-6

Alias Guanylin (human)

Endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.

Guanylin(human)

😃Good

Catalog No. TP2034Alias Guanylin (human)Cas No. 183200-12-6

Endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 μg	$1,130	35 days	35 days

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Product Introduction

Bioactivity

Description	Endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.
Synonyms	Guanylin (human)

Chemical Properties

Molecular Weight	1458.65
Formula	C₅₈H₈₇N₁₅O₂₁S₄
Cas No.	183200-12-6
Smiles	C([C@@H]1NC(=O)[C@H](C)NC(=O)[C@]2(NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC([C@@H](NC(CNC(=O)[C@@H]3CCCN3)=O)[C@@H](C)O)=O)CSSC[C@](NC(=O)[C@H](C)NC(=O)[C@H](C)NC1=O)(C(=O)N[C@@]([C@@H](C)O)(C(=O)NCC(=O)N[C@H](C(O)=O)CSSC2)[H])[H])[H])[H])C4=CC=C(O)C=C4
Relative Density.	1.49 g/cm3 (Predicted)
Sequence	H-Pro-Gly-Thr-Cys(1)-Glu-Ile-Cys(2)-Ala-Tyr-Ala-Ala-Cys(1)-Thr-Gly-Cys(2)-OH
Sequence Short	PGTCEICAYAACTGC (Disulfide bridge:Cys4-Cys12;Cys7-Cys15)

Storage & Solubility Information

Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O: 1 mg/mL (0.69 mM), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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