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DTE

Name: DTE
Brand: TargetMol
SKU: T19299
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19299Cas No. 6892-68-8

Alias Dithioerythritol, Cleland's reagent

DTE (Dithioerythritol) is a sulfur-containing sugar derivative of the four-carbon monosaccharide erythrose and is an epimer of dithiothreitol (DTT), Dithioerythritol (DTE) is commonly used as a reducing agent in biochemical and molecular biology experiments to maintain thiol groups in a reduced state, stabilize protein structure, and support redox-sensitive enzymatic and structural studies.

DTE

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Catalog No. T19299Alias Dithioerythritol, Cleland's reagentCas No. 6892-68-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$42	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:White

Resource Download

COA MS HNMR

Product Introduction

Bioactivity

Description	DTE (Dithioerythritol) is a sulfur-containing sugar derivative of the four-carbon monosaccharide erythrose and is an epimer of dithiothreitol (DTT), Dithioerythritol (DTE) is commonly used as a reducing agent in biochemical and molecular biology experiments to maintain thiol groups in a reduced state, stabilize protein structure, and support redox-sensitive enzymatic and structural studies.
In vivo	In a mouse model of bile duct ligation (BDL)-induced cholestasis, administration of DTE in drinking water (0.25%-1% v/v) reduced hepatic and renal damage. The treatment was associated with a reduction in Oxidative Stress markers and the amelioration of physiological symptoms, including hepatomegaly and splenomegaly [3].
Synonyms	Dithioerythritol, Cleland's reagent

Chemical Properties

Molecular Weight	154.25
Formula	C₄H₁₀O₂S₂
Cas No.	6892-68-8
Smiles	[C@H]([C@H](CS)O)(CS)O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year

Solubility Information

H2O: 40 mg/mL (259.32 mM), Sonication is recommended.

DMSO: 80 mg/mL (518.64 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4830 mL	32.4149 mL	64.8298 mL	324.1491 mL
5 mM	1.2966 mL	6.4830 mL	12.9660 mL	64.8298 mL
10 mM	0.6483 mL	3.2415 mL	6.4830 mL	32.4149 mL
20 mM	0.3241 mL	1.6207 mL	3.2415 mL	16.2075 mL
50 mM	0.1297 mL	0.6483 mL	1.2966 mL	6.4830 mL
100 mM	0.0648 mL	0.3241 mL	0.6483 mL	3.2415 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

DTE