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Antibacterial agent 327
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Catalog No. T218702 Copy Product Info
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Antibacterialagent 327 (Compound 6f) is an antibacterial agent that effectively inhibits the supercoiling activity of Staphylococcus aureus DNA gyrase with an IC50 of 0.28 μM. It also inhibits the ATPase activities of DNA gyrase and Topoisomerase IV, as well as the decatenation activity of Topoisomerase IV, with IC50 values of 0.43 μM, 0.73 μM, and 2.31 μM, respectively. Furthermore, Antibacterialagent 327 powerfully suppresses Clostridium difficile and Methicillin-resistant Staphylococcus aureus, with both having a minimum inhibitory concentration (MIC) of 0.78 μg/mL. It also inhibits Escherichia coli, with a MIC50 of 0.78 μg/mL.
Antibacterial agent 327
Cas No. 1311163-39-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Antibacterialagent 327 (Compound 6f) is an antibacterial agent that effectively inhibits the supercoiling activity of Staphylococcus aureus DNA gyrase with an IC50 of 0.28 μM. It also inhibits the ATPase activities of DNA gyrase and Topoisomerase IV, as well as the decatenation activity of Topoisomerase IV, with IC50 values of 0.43 μM, 0.73 μM, and 2.31 μM, respectively. Furthermore, Antibacterialagent 327 powerfully suppresses Clostridium difficile and Methicillin-resistant Staphylococcus aureus, with both having a minimum inhibitory concentration (MIC) of 0.78 μg/mL. It also inhibits Escherichia coli, with a MIC50 of 0.78 μg/mL. |
| Targets & IC50 | TOPO IV:2.31 μM |
| In vitro | Antibacterial agent 327 effectively inhibits Clostridium difficile and Methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 0.78 μg/mL for both. This compound shows potent inhibition of Escherichia coli at concentrations of 0.78-100 μg/mL, with an MIC 50 of 0.78 μg/mL, but exhibits weaker activity against Pseudomonas aeruginosa and Salmonella typhimurium and limited activity against Klebsiella pneumoniae. It also strongly inhibits the supercoiling activity of Staphylococcus aureus DNA gyrase with an IC 50 of 0.28 μM, and it hinders both the ATPase activity of DNA gyrase and topoisomerase IV and the decatenation activity of topoisomerase IV. For fibroblast WI-38 cells, Antibacterial agent 327 has an IC 50 of 85.52 μM. |
| Molecular Weight | 832.23 |
| Formula | C34H42ClN3O17S |
| Cas No. | 1311163-39-9 |
| Smiles | O([C@H]1[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](NC(NN=CC2=CC=C(Cl)C=C2)=S)O[C@@H]1COC(C)=O)[C@@H]3[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Antibacterial agent 327 in vitro | Antibacterial agent 327 formula | Antibacterial agent 327 molecular weight
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