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Cyclic GMP (TBAOH)
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Catalog No. TNU1680
Cyclic GMP TBAOH is an endogenous second messenger that triggers the production of interferons in response to cytosolic DNA. It activates the stimulator of interferon genes (STING), initiating a signaling cascade that produces type I interferons and other immune mediators. The conjugate of Cyclic GMP TBAOH and AMP, known as Cyclic-GMP-AMP, can induce IRF3 phosphorylation and nuclear translocation to enhance antiviral immune responses. Additionally, Cyclic GMP TBAOH may activate PDE to degrade cAMP, inhibit the calcium current ICa in cardiomyocytes, and regulate myocardial contractility. Its derivative, 8-Br-cGMP, exhibits antiplatelet activity, making Cyclic GMP TBAOH useful for research in antiviral immunity and cardiovascular diseases.
Cyclic GMP (TBAOH)
Cyclic GMP (TBAOH)
Copy Product Info😃Good
Catalog No. TNU1680
Cyclic GMP TBAOH is an endogenous second messenger that triggers the production of interferons in response to cytosolic DNA. It activates the stimulator of interferon genes (STING), initiating a signaling cascade that produces type I interferons and other immune mediators. The conjugate of Cyclic GMP TBAOH and AMP, known as Cyclic-GMP-AMP, can induce IRF3 phosphorylation and nuclear translocation to enhance antiviral immune responses. Additionally, Cyclic GMP TBAOH may activate PDE to degrade cAMP, inhibit the calcium current ICa in cardiomyocytes, and regulate myocardial contractility. Its derivative, 8-Br-cGMP, exhibits antiplatelet activity, making Cyclic GMP TBAOH useful for research in antiviral immunity and cardiovascular diseases.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cyclic GMP TBAOH is an endogenous second messenger that triggers the production of interferons in response to cytosolic DNA. It activates the stimulator of interferon genes (STING), initiating a signaling cascade that produces type I interferons and other immune mediators. The conjugate of Cyclic GMP TBAOH and AMP, known as Cyclic-GMP-AMP, can induce IRF3 phosphorylation and nuclear translocation to enhance antiviral immune responses. Additionally, Cyclic GMP TBAOH may activate PDE to degrade cAMP, inhibit the calcium current ICa in cardiomyocytes, and regulate myocardial contractility. Its derivative, 8-Br-cGMP, exhibits antiplatelet activity, making Cyclic GMP TBAOH useful for research in antiviral immunity and cardiovascular diseases. |
| In vitro | ACh stimulates the accumulation of Cyclic GMP (cGMP) TBAOH, activating cGMP-mediated protein kinase. The increase in Cyclic GMP TBAOH reduces Ca ion influx, thereby shortening action potentials and inhibiting I Ca. When Cyclic GMP TBAOH (1 μM; 3-5 min) acts with Isoprenaline, it activates Cyclic GMP TBAOH-stimulated phosphodiesterase, reversing cAMP-mediated enhancement or inhibiting cAMP-induced inward calcium current (I Ca). |
| Storage | In solvent: -80°C for 1 year |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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