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Macitentan-d4

Name: Macitentan-d4
Brand: TargetMol
SKU: T11934
Rating: 4.5 (1 reviews)

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Catalog No. T11934Cas No. 1258428-05-5

Alias Macitentan D4, ACT-064992 D4

Macitentan-d4 (ACT-064992 D4) is a deuterated substitute for Macitentan and can be used as a dual antagonist of the non-peptides ETA and ETB (endothelin receptor).Macitentan-d4 is less toxic than Macitentan, has a longer half-life, and can be used to study endothelin receptor-mediated diseases.

Macitentan-d4

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Purity: 96.51%

Catalog No. T11934Alias Macitentan D4, ACT-064992 D4Cas No. 1258428-05-5

Pack Size	Price	Availability	Quantity
1 mg	$263	7-10 days
5 mg	$662	7-10 days

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Purity:96.51%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Macitentan-d4 (ACT-064992 D4) is a deuterated substitute for Macitentan and can be used as a dual antagonist of the non-peptides ETA and ETB (endothelin receptor).Macitentan-d4 is less toxic than Macitentan, has a longer half-life, and can be used to study endothelin receptor-mediated diseases.
Synonyms	Macitentan D4, ACT-064992 D4

Chemical Properties

Molecular Weight	592.3
Formula	C₁₉H₂₀Br₂N₆O₄S
Cas No.	1258428-05-5
Smiles	N(S(NCCC)(=O)=O)C=1C(=C(OC(C(OC=2N=CC(Br)=CN2)([2H])[2H])([2H])[2H])N=CN1)C3=CC=C(Br)C=C3
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (33.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6883 mL	8.4417 mL	16.8833 mL	84.4167 mL
5 mM	0.3377 mL	1.6883 mL	3.3767 mL	16.8833 mL
10 mM	0.1688 mL	0.8442 mL	1.6883 mL	8.4417 mL
20 mM	0.0844 mL	0.4221 mL	0.8442 mL	4.2208 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc