Chamaejasmenin B is a compound isolated from Stellera chamaejasme L. Chamaejasmenin B has anticancer and antitumor activity, inhibiting cancer cell migration and invasion, and inhibiting tumor metastasis.Chamaejasmenin B is used in the study of cancers such as breast cancer.

Chamaejasmenin B exerted potent anti-proliferative effects in the 8 human solid tumor cell lines (HepG2, SMMC-7721, A549, MG63, U2OS, KHOS, HCT-116, and HeLa) with the IC50 values ranging from 1.08 to 10.8 μmol/L)) values ranged from 3.07 to 15.97 μmol/L). In the most sensitive A549 and KHOS cells, the mechanisms underlying the antiproliferative effects were characterized. The two compounds induced prominent expression of the DNA damage marker γ-H2AX as well as apoptosis. Furthermore, treatment of the cells with the two compounds caused prominent G(0)/G(1) phase arrest.[3]