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Pantethine

Name: Pantethine
Brand: TargetMol
SKU: T0978
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0978Cas No. 16816-67-4

Alias Pantosin, Pantomin, Pantetina, LBF disulfide, D-Pantethine, Bis-pantethine

Pantethine (Pantomin) (Bis-pantethine) is a dimeric form of vitamin B5. Pantethine is less stable than pantothenic acid and tends to decompose over time if it is not kept refrigerated, so most vitamin B5 supplements are in the form of calcium pantothenate. It is available as a dietary supplement and is used to treat acne and improve the blood-cholesterol profile.

Pantethine

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Purity: 99.99%

Catalog No. T0978Alias Pantosin, Pantomin, Pantetina, LBF disulfide, D-Pantethine, Bis-pantethineCas No. 16816-67-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

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COA HNMR LCMS

Product Introduction

Pantethine AI Summary

Pantethine exhibited low antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells at a multiplicity of infection (MOI) of 0.4 after 96 hours, with a hit score of 0.0893. Additionally, this compound shows a broad profile of activity in various assays but does not demonstrate significant bioactivity in terms of binding affinity or inhibition for the tested targets, as indicated by AC50 values greater than 30,000.0 nM in all assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pantethine (Pantomin) (Bis-pantethine) is a dimeric form of vitamin B5. Pantethine is less stable than pantothenic acid and tends to decompose over time if it is not kept refrigerated, so most vitamin B5 supplements are in the form of calcium pantothenate. It is available as a dietary supplement and is used to treat acne and improve the blood-cholesterol profile.
Synonyms	Pantosin, Pantomin, Pantetina, LBF disulfide, D-Pantethine, Bis-pantethine

Chemical Properties

Molecular Weight	554.72
Formula	C₂₂H₄₂N₄O₈S₂
Cas No.	16816-67-4
Smiles	CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO
Relative Density.	1.277g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (180.27 mM), Sonication is recommended.

H2O: 100 mg/mL (180.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.8027 mL	9.0136 mL	18.0271 mL	90.1356 mL
5 mM	0.3605 mL	1.8027 mL	3.6054 mL	18.0271 mL
10 mM	0.1803 mL	0.9014 mL	1.8027 mL	9.0136 mL
20 mM	0.0901 mL	0.4507 mL	0.9014 mL	4.5068 mL
50 mM	0.0361 mL	0.1803 mL	0.3605 mL	1.8027 mL
100 mM	0.0180 mL	0.0901 mL	0.1803 mL	0.9014 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc