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Hex

Name: Hex
Brand: TargetMol
SKU: T39419
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39419Cas No. 2004714-32-1

Hex is an enolase inhibitor and antimalarial agent with Ki values of 74.4 nM and 269.4 nM against ENO2 and ENO1, respectively; its IC50 values against NfENO and TbENO are 0.14 μM and 2.1 μM, respectively. Hex exhibits antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites, and Plasmodium berghei ANKA strain, and also shows certain antitumor effects against intracranial tumors.

Hex

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Catalog No. T39419Cas No. 2004714-32-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$215	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Brown

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COA

Product Introduction

Bioactivity

Description	Hex is an enolase inhibitor and antimalarial agent with Ki values of 74.4 nM and 269.4 nM against ENO2 and ENO1, respectively; its IC50 values against NfENO and TbENO are 0.14 μM and 2.1 μM, respectively. Hex exhibits antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites, and Plasmodium berghei ANKA strain, and also shows certain antitumor effects against intracranial tumors.
Targets&IC50	ENO2:74.4 nM (Ki), ENO1:269.4 nM (Ki)
In vitro	Hex (1-week treatment) is toxic to D423 (ENO1) cells, with an IC50 of approximately 1.3 μM [1]. Hex is a potent NfENO inhibitor with an IC50 of 0.14 μM [2]. Hex (48-hour treatment) significantly inhibits the proliferation of Naegleria fowleri trophozoites, with an EC50 of 0.21 μM [2]. Hex inhibits TbENO with an IC50 of 2.1 μM [3]. Hex shows weak antimalarial activity against Plasmodium falciparum strain 3D7, with an EC50 > 15 μM [6].
In vivo	Hex (150 mg/kg, intravenous and intraperitoneal injection, once daily for 1 week) significantly inhibits tumor growth in a mouse intracranial tumor model, with complete regression of some tumors and no recurrence after long-term treatment [1]. Hex (3 mg/kg, intranasal instillation, once daily for 10 days) prolongs the survival of rats infected with Naegleria fowleri, but cannot achieve complete cure [2]. Hex (100 mg/kg, intraperitoneal injection, once daily for 5 days) reduces the overall parasite burden, improves clinical scores, and significantly increases the survival rate of mice infected with Plasmodium berghei ANKA strain [7].

Chemical Properties

Molecular Weight	195.11
Formula	C₅H₁₀NO₅P
Cas No.	2004714-32-1
Smiles	O=C1N(O)CCCC1P(=O)(O)O

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112 mg/mL (574.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1253 mL	25.6266 mL	51.2531 mL	256.2657 mL
5 mM	1.0251 mL	5.1253 mL	10.2506 mL	51.2531 mL
10 mM	0.5125 mL	2.5627 mL	5.1253 mL	25.6266 mL
20 mM	0.2563 mL	1.2813 mL	2.5627 mL	12.8133 mL
50 mM	0.1025 mL	0.5125 mL	1.0251 mL	5.1253 mL
100 mM	0.0513 mL	0.2563 mL	0.5125 mL	2.5627 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Hex

Hex

Hex

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