Melflufen hydrochloride

Name: Melflufen hydrochloride
Brand: TargetMol
SKU: T40478
Rating: 4.5 (1 reviews)

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Catalog No. T40478Cas No. 380449-54-7

Alias Melphalan flufenamide hydrochloride, Melflufen hydrochloride

Melflufen (Melphalan flufenamide) hydrochloride, an alkylating agent and dipeptide prodrug of Melphalan, exhibits antitumor activity by inducing irreversible DNA damage and cytotoxicity in multiple myeloma (MM) cells, while also inhibiting angiogenesis.

Melflufen hydrochloride

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Catalog No. T40478Alias Melphalan flufenamide hydrochloride, Melflufen hydrochlorideCas No. 380449-54-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$378	7-10 days	7-10 days

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Product Introduction

Bioactivity

Description	Melflufen (Melphalan flufenamide) hydrochloride, an alkylating agent and dipeptide prodrug of Melphalan, exhibits antitumor activity by inducing irreversible DNA damage and cytotoxicity in multiple myeloma (MM) cells, while also inhibiting angiogenesis.
In vitro	Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM; 24 hours) significantly reduces the viability of multiple myeloma cells (MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, ANBL-6) in a concentration-dependent manner, induces apoptosis in MM.1S cells, and potently activates exosome secretion[1][3].
In vivo	Melflufen (Melphalan flufenamide) hydrochloride, administered intravenously at a dosage of 3 mg/kg twice weekly for two weeks, demonstrates significant anti-multiple myeloma (MM) activity in a human plasmacytoma MM.1S xenograft mouse model using CB-17 SCID mice. This treatment notably inhibited MM tumor growth and extended the survival of the mice.
Synonyms	Melphalan flufenamide hydrochloride, Melflufen hydrochloride

Chemical Properties

Molecular Weight	534.88
Formula	C₂₄H₃₁Cl₃FN₃O₃
Cas No.	380449-54-7
Smiles	Cl.CCOC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](N)Cc1ccc(cc1)N(CCCl)CCCl

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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