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N-Acetyl-L-histidine monohydrate

Catalog No. T38094 Copy Product Info
Purity: 99.96%
🥰Excellent
N-Acetyl-L-histidine monohydrate (NAH) is a histidine derivative and a prominent biomolecule found in the brain, retina, and lens of poikilothermic (cold-blooded) vertebrates. It functions as an essential animal metabolite and serves as a major osmolyte in the brain and ocular tissues of teleost fish, amphibians, and reptiles. Unlike poikilotherms, homeothermic (endothermic) vertebrates exhibit significantly lower levels of NAH in the brain and other tissues, highlighting its unique phylogenetic distribution and specialized physiological role in evolutionary biology and vertebrate homeostasis.

N-Acetyl-L-histidine monohydrate

Copy Product Info
🥰Excellent
Catalog No. T38094

N-Acetyl-L-histidine monohydrate (NAH) is a histidine derivative and a prominent biomolecule found in the brain, retina, and lens of poikilothermic (cold-blooded) vertebrates. It functions as an essential animal metabolite and serves as a major osmolyte in the brain and ocular tissues of teleost fish, amphibians, and reptiles. Unlike poikilotherms, homeothermic (endothermic) vertebrates exhibit significantly lower levels of NAH in the brain and other tissues, highlighting its unique phylogenetic distribution and specialized physiological role in evolutionary biology and vertebrate homeostasis.

N-Acetyl-L-histidine monohydrate
Cas No. 39145-52-3
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Pack SizePriceUSA StockGlobal StockQuantity
1 g$29-In Stock
5 g$81-In Stock
10 g$118-In Stock
1 mL x 10 mM (in DMSO)$29-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:99.96%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
N-Acetyl-L-histidine monohydrate (NAH) is a histidine derivative and a prominent biomolecule found in the brain, retina, and lens of poikilothermic (cold-blooded) vertebrates. It functions as an essential animal metabolite and serves as a major osmolyte in the brain and ocular tissues of teleost fish, amphibians, and reptiles. Unlike poikilotherms, homeothermic (endothermic) vertebrates exhibit significantly lower levels of NAH in the brain and other tissues, highlighting its unique phylogenetic distribution and specialized physiological role in evolutionary biology and vertebrate homeostasis.
In vitro
N-Acetyl-L-histidine monohydrate is a key osmolyte in the brain and eyes of fish, amphibians, and reptiles, regulating cell volume and intraocular pressure. Its scarcity in homeotherms makes it a valuable probe for studying vertebrate thermal adaptation and brain metabolism evolution [1].
Chemical Properties
Molecular Weight215.21
FormulaC8H13N3O4
Cas No.39145-52-3
Smiles[C@@H](CC1=CN=CN1)(NC(C)=O)C(O)=O.O
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 16 mg/mL (74.35 mM), Sonication is recommended.
H2O: 50 mg/mL (232.33 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM4.6466 mL23.2331 mL46.4662 mL232.3312 mL
5 mM0.9293 mL4.6466 mL9.2932 mL46.4662 mL
10 mM0.4647 mL2.3233 mL4.6466 mL23.2331 mL
20 mM0.2323 mL1.1617 mL2.3233 mL11.6166 mL
50 mM0.0929 mL0.4647 mL0.9293 mL4.6466 mL
H2O
1mg5mg10mg50mg
100 mM0.0465 mL0.2323 mL0.4647 mL2.3233 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

N-Acetyl-L-histidine MonohydrateNAcetylLhistidine monohydrateN-Acetyl-L-histidineN Acetyl L histidine monohydrate
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