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Talaroterphenyl A
🥰Excellent
Catalog No. TN11229
Talaroterphenyl A (compound 1) is a p-terphenyl derivative isolated from the fungus Talaromyces sp. SCSIO 41412, found in mangrove sediment. It acts as a phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 1.2 μM. Additionally, Talaroterphenyl A exhibits anti-inflammatory and antifibrotic properties, significantly reducing mRNA levels of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β.
Talaroterphenyl A
Talaroterphenyl A
🥰Excellent
Catalog No. TN11229
Talaroterphenyl A (compound 1) is a p-terphenyl derivative isolated from the fungus Talaromyces sp. SCSIO 41412, found in mangrove sediment. It acts as a phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 1.2 μM. Additionally, Talaroterphenyl A exhibits anti-inflammatory and antifibrotic properties, significantly reducing mRNA levels of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Talaroterphenyl A (compound 1) is a p-terphenyl derivative isolated from the fungus Talaromyces sp. SCSIO 41412, found in mangrove sediment. It acts as a phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 1.2 μM. Additionally, Talaroterphenyl A exhibits anti-inflammatory and antifibrotic properties, significantly reducing mRNA levels of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β. |
| Targets&IC50 | PDE4:1.2 μM |
| Formula | C22H20O5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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