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Darifenacin

Name: Darifenacin
Brand: TargetMol
SKU: T62320
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62320Cas No. 133099-04-4

Alias UK-88525, UK88525

Darifenacin (UK-88525) is a muscarinic receptor M3 antagonist with anticonvulsant activity and can be used to study urinary incontinence and overactive bladder.

Darifenacin

🥰Excellent

Purity: 99.78%

Catalog No. T62320Alias UK-88525, UK88525Cas No. 133099-04-4

Darifenacin (UK-88525) is a muscarinic receptor M3 antagonist with anticonvulsant activity and can be used to study urinary incontinence and overactive bladder.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$59	In Stock
10 mg	$94	In Stock
25 mg	$172	In Stock
50 mg	$277	In Stock
100 mg	$416	In Stock
200 mg	$593	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock

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Purity:99.78%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Darifenacin (UK-88525) is a muscarinic receptor M3 antagonist with anticonvulsant activity and can be used to study urinary incontinence and overactive bladder.
Targets&IC50	ATPase activity (P-gp membranes:1.6 μM (ED50)
In vitro	Darifenacin increased the accumulation of R123 (P-gp probe) in a concentration-dependent manner in MDCK cells. [1] Darifenacin stimulated ATPase activity in P-gp membranes in a concentration-dependent manner with an estimated ED50 = 1.6 μM. [1] 100 nM Darifenacin showed higher permeability in the basolateral to apical direction, leading to an exocytosis ratio of ~2.6 in BBMEC monolayer cells. [1]
In vivo	Darifenacin dose-dependently inhibited volume-induced bladder contraction amplitude (VIBCAMP), with 283.3 nmol/kg Darifenacin producing a 35% inhibition, with a maximum inhibition of approximately 50-55%. [2] Intravenous injection of 0.1 mg/kg Darifenacin in female Sprague-Dawley rats reduced bladder afferent activity in Aδ and C fibers, where the reduction in afferent spikes may be more pronounced in C fibers than in Aδ fibers. [3]
Synonyms	UK-88525, UK88525

Chemical Properties

Molecular Weight	426.55
Formula	C₂₈H₃₀N₂O₂
Cas No.	133099-04-4
Smiles	C(C(N)=O)([C@H]1CN(CCC=2C=C3C(=CC2)OCC3)CC1)(C4=CC=CC=C4)C5=CC=CC=C5

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (187.55 mM.), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3444 mL	11.7220 mL	23.4439 mL	117.2196 mL
5 mM	0.4689 mL	2.3444 mL	4.6888 mL	23.4439 mL
10 mM	0.2344 mL	1.1722 mL	2.3444 mL	11.7220 mL
20 mM	0.1172 mL	0.5861 mL	1.1722 mL	5.8610 mL
50 mM	0.0469 mL	0.2344 mL	0.4689 mL	2.3444 mL
100 mM	0.0234 mL	0.1172 mL	0.2344 mL	1.1722 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc