Antimalarial agent 49

Name: Antimalarial agent 49
Brand: TargetMol
SKU: T206643
Rating: 4.5 (1 reviews)

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Catalog No. T206643

Antimalarial agent 49 is an oral compound with antimalarial properties. It inhibits the growth of Pf3D7 and PfK1 strains, with IC50 values of 0.84 μM and 0.4 μM, respectively. Additionally, it demonstrates the ability to suppress the liver stage development of P. berghei and can be utilized in malaria infection research.

Antimalarial agent 49

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Catalog No. T206643

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	Backorder
50 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	Antimalarial agent 49 is an oral compound with antimalarial properties. It inhibits the growth of Pf3D7 and PfK1 strains, with IC50 values of 0.84 μM and 0.4 μM, respectively. Additionally, it demonstrates the ability to suppress the liver stage development of P. berghei and can be utilized in malaria infection research.
In vitro	Antimalarial agent 49 (compound 15k) inhibits the development of P. berghei during the liver stage with an IC50 of 5.88 μM, when used in concentrations ranging from 0.37 to 10 μM over a period of 40 hours.
In vivo	Compound 15k (Antimalarial agent 49), administered orally at a dosage of 100 mg/kg once daily for four days, inhibits parasite growth by 35.93% in a P. yoelii N67 infection model in mice.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc