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PD 81723

Name: PD 81723
Brand: TargetMol
SKU: T23130
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23130Cas No. 132861-87-1

Alias PD-81723, PD81723

PD 81723 is an adenosine receptor binding enhancer that potentiates the inhibitory effects of exogenous adenosine in a dose-dependent manner in hippocampal brain sections, PD 81723 is commonly applied in neuroscience research to investigate adenosine receptor modulation, synaptic transmission, neuromodulation, and neuroprotective signaling pathways.

PD 81723

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Purity: 99.97%

Catalog No. T23130Alias PD-81723, PD81723Cas No. 132861-87-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	-	In Stock
5 mg	$89	-	In Stock
10 mg	$143	-	In Stock
25 mg	$328	-	In Stock
50 mg	$533	-	In Stock
100 mg	$855	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PD 81723 is an adenosine receptor binding enhancer that potentiates the inhibitory effects of exogenous adenosine in a dose-dependent manner in hippocampal brain sections, PD 81723 is commonly applied in neuroscience research to investigate adenosine receptor modulation, synaptic transmission, neuromodulation, and neuroprotective signaling pathways.
In vitro	In rat hippocampal slices, PD 81723 (10-50 μM) acted as a selective allosteric enhancer of the Adenosine A1 receptor. It potentiated the inhibitory effect of adenosine and 2-chloroadenosine on synaptic transmission and enhanced the depression of population spike amplitude in the CA1 region [1].
Synonyms	PD-81723, PD81723

Chemical Properties

Molecular Weight	299.31
Formula	C₁₄H₁₂F₃NOS
Cas No.	132861-87-1
Smiles	O=C(C1=CC=CC(=C1)C(F)(F)F)C2=C(SC(=C2C)C)N
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (267.28 mM), Sonication is recommended.

Ethanol: <29.93 mg/mL, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3410 mL	16.7051 mL	33.4102 mL	167.0509 mL
5 mM	0.6682 mL	3.3410 mL	6.6820 mL	33.4102 mL
10 mM	0.3341 mL	1.6705 mL	3.3410 mL	16.7051 mL
20 mM	0.1671 mL	0.8353 mL	1.6705 mL	8.3525 mL
50 mM	0.0668 mL	0.3341 mL	0.6682 mL	3.3410 mL
100 mM	0.0334 mL	0.1671 mL	0.3341 mL	1.6705 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc