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Hexacyclen (Synonyms: Hexaaza-18-crown-6, 1,4,7,10,13,16-Hexazacyclooctadecane)

Name: Hexacyclen
Brand: TargetMol
SKU: T84874
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T84874 Copy Product Info

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Hexacyclen is an analogue of 18-crown-6, exhibiting antagonistic and blocking effects on the extracellular calcium-sensing receptor with an EC50 of 20 μM. Possessing multiple secondary amine groups, Hexacyclen serves as an excellent electron donor and functions as a block copolymer.

Hexacyclen

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Catalog No. T84874

Synonyms Hexaaza-18-crown-6, 1,4,7,10,13,16-Hexazacyclooctadecane

Cas No. 296-35-5

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	Hexacyclen is an analogue of 18-crown-6, exhibiting antagonistic and blocking effects on the extracellular calcium-sensing receptor with an EC50 of 20 μM. Possessing multiple secondary amine groups, Hexacyclen serves as an excellent electron donor and functions as a block copolymer.
In vitro	Hexacyclen is a biochemical reagent with application value in the fields of biomaterials or organic compound research, suitable for life science-related studies.
Synonyms	Hexaaza-18-crown-6, 1,4,7,10,13,16-Hexazacyclooctadecane

Chemical Properties

Molecular Weight	258.41
Formula	C₁₂H₃₀N₆
Cas No.	296-35-5
Smiles	N1CCNCCNCCNCCNCCNCC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 80 mg/mL (309.59 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.8698 mL	19.3491 mL	38.6982 mL	193.4910 mL
5 mM	0.7740 mL	3.8698 mL	7.7396 mL	38.6982 mL
10 mM	0.3870 mL	1.9349 mL	3.8698 mL	19.3491 mL
20 mM	0.1935 mL	0.9675 mL	1.9349 mL	9.6745 mL
50 mM	0.0774 mL	0.3870 mL	0.7740 mL	3.8698 mL
100 mM	0.0387 mL	0.1935 mL	0.3870 mL	1.9349 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc