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LY231617

Name: LY231617
Brand: TargetMol
SKU: T22942
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22942Cas No. 141545-89-3

Alias LY-231617

LY231617 is an orally bioavailable, blood-brain barrier-penetrant antioxidant that mitigates systemic ischaemic neuronal injury in rats. It exerts neuroprotective effects against H₂O₂-induced toxicity by inhibiting lipid peroxidation.

LY231617

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Purity: 97.48%

Catalog No. T22942Alias LY-231617Cas No. 141545-89-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	-	In Stock
5 mg	$73	-	In Stock
10 mg	$113	-	In Stock
25 mg	$239	-	In Stock
50 mg	$347	-	In Stock
100 mg	$538	-	In Stock
1 mL x 10 mM (in DMSO)	$80	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.48%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	LY231617 is an orally bioavailable, blood-brain barrier-penetrant antioxidant that mitigates systemic ischaemic neuronal injury in rats. It exerts neuroprotective effects against H₂O₂-induced toxicity by inhibiting lipid peroxidation.
In vitro	After co-incubation with hippocampal cells overnight, LY231617 (0.25-25 μM) attenuated the toxicity of H₂O₂ on hippocampal cell cultures, with the most significant effect observed at 10 μM [1]. Overnight incubation with LY231617 (5 μM) inhibited prostaglandin production in 8-parazacco spilurus subsp. spilurus and prevented glutathione depletion [1].
In vivo	In the rat four-vessel occlusion model, LY231617 (50 mg/kg) administered orally 30 minutes before ischemia significantly alleviated neuronal damage [2]. LY231617 (20 mg/kg) administered intravenously 30 minutes after ischemia effectively protected the hippocampus and striatum from damage caused by four-vessel occlusion [2].
Synonyms	LY-231617

Chemical Properties

Molecular Weight	299.88
Formula	C₁₇H₃₀ClNO
Cas No.	141545-89-3
Smiles	Cl.OC=1C(=CC(=CC1C(C)(C)C)CNCC)C(C)(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (666.93 mM), Sonication is recommended.

Ethanol: <29.99 mg/mL, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3347 mL	16.6733 mL	33.3467 mL	166.7334 mL
5 mM	0.6669 mL	3.3347 mL	6.6693 mL	33.3467 mL
10 mM	0.3335 mL	1.6673 mL	3.3347 mL	16.6733 mL
20 mM	0.1667 mL	0.8337 mL	1.6673 mL	8.3367 mL
50 mM	0.0667 mL	0.3335 mL	0.6669 mL	3.3347 mL
100 mM	0.0333 mL	0.1667 mL	0.3335 mL	1.6673 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc