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LY231617

Name: LY231617
Brand: TargetMol
SKU: T22942
Rating: 4.5 (1 reviews)

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Catalog No. T22942Cas No. 141545-89-3

Alias LY-231617

LY231617 is an orally bioavailable, blood-brain barrier-penetrant antioxidant that mitigates systemic ischaemic neuronal injury in rats. It exerts neuroprotective effects against H₂O₂-induced toxicity by inhibiting lipid peroxidation.

LY231617

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Purity: 97.48%

Catalog No. T22942Alias LY-231617Cas No. 141545-89-3

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Purity:97.48%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	LY231617 is an orally bioavailable, blood-brain barrier-penetrant antioxidant that mitigates systemic ischaemic neuronal injury in rats. It exerts neuroprotective effects against H₂O₂-induced toxicity by inhibiting lipid peroxidation.
In vitro	After co-incubation with hippocampal cells overnight, LY231617 (0.25-25 μM) attenuated the toxicity of H₂O₂ on hippocampal cell cultures, with the most significant effect observed at 10 μM [1]. Overnight incubation with LY231617 (5 μM) inhibited prostaglandin production in 8-parazacco spilurus subsp. spilurus and prevented glutathione depletion [1].
In vivo	In the rat four-vessel occlusion model, LY231617 (50 mg/kg) administered orally 30 minutes before ischemia significantly alleviated neuronal damage [2]. LY231617 (20 mg/kg) administered intravenously 30 minutes after ischemia effectively protected the hippocampus and striatum from damage caused by four-vessel occlusion [2].
Synonyms	LY-231617

Chemical Properties

Molecular Weight	299.88
Formula	C₁₇H₃₀ClNO
Cas No.	141545-89-3
Smiles	Cl.OC=1C(=CC(=CC1C(C)(C)C)CNCC)C(C)(C)C
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (666.93 mM), Sonication is recommended.

Ethanol: <29.99 mg/mL, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3347 mL	16.6733 mL	33.3467 mL	166.7334 mL
5 mM	0.6669 mL	3.3347 mL	6.6693 mL	33.3467 mL
10 mM	0.3335 mL	1.6673 mL	3.3347 mL	16.6733 mL
20 mM	0.1667 mL	0.8337 mL	1.6673 mL	8.3367 mL
50 mM	0.0667 mL	0.3335 mL	0.6669 mL	3.3347 mL
100 mM	0.0333 mL	0.1667 mL	0.3335 mL	1.6673 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc