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Dithizone

Name: Dithizone
Brand: TargetMol
SKU: TXB-00004
Rating: 4.5 (1 reviews)

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Catalog No. TXB-00004Cas No. 60-10-6

Alias Diphenylthiocarbazone

Dithizone (Diphenylthiocarbazone, DTZ) is a sulphur-containing metal ligand for the separation and determination of trace metal ions. It possesses potential for inducing experimental diabetes and is also employed for islet staining.

Dithizone

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Catalog No. TXB-00004Alias DiphenylthiocarbazoneCas No. 60-10-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$48	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Dithizone (Diphenylthiocarbazone, DTZ) is a sulphur-containing metal ligand for the separation and determination of trace metal ions. It possesses potential for inducing experimental diabetes and is also employed for islet staining.
In vitro	Dithizone (0.2 mM, 5-10 minutes) stains isolated canine and porcine islet cells red, whereas under the same conditions, bovine islet cells do not exhibit coloration [1]. When islet cells stained with Dithizone (0.4 mM) are subsequently exposed to 300 μg/mL of 8-hydroxyquinoline, the original staining gradually fades within 5-10 minutes [1]. Prolonged exposure of islet cells to Dithizone (20 μg/mL) for 4-48 hours results in decreased insulin secretion and induces islet cell death [1].
Synonyms	Diphenylthiocarbazone

Chemical Properties

Molecular Weight	256.33
Formula	C₁₃H₁₂N₄S
Cas No.	60-10-6
Smiles	S=C(/N=N/C1=CC=CC=C1)NNC2=CC=CC=C2

Storage & Solubility Information

Storage

store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (156.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (7.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9012 mL	19.5061 mL	39.0122 mL	195.0611 mL
5 mM	0.7802 mL	3.9012 mL	7.8024 mL	39.0122 mL
10 mM	0.3901 mL	1.9506 mL	3.9012 mL	19.5061 mL
20 mM	0.1951 mL	0.9753 mL	1.9506 mL	9.7531 mL
50 mM	0.0780 mL	0.3901 mL	0.7802 mL	3.9012 mL
100 mM	0.0390 mL	0.1951 mL	0.3901 mL	1.9506 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc