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Dithizone

Name: Dithizone
Brand: TargetMol
SKU: TXB-00004
Rating: 4.5 (1 reviews)

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Catalog No. TXB-00004Cas No. 60-10-6

Alias Diphenylthiocarbazone

Dithizone (Diphenylthiocarbazone, DTZ) is a sulphur-containing metal ligand for the separation and determination of trace metal ions. It possesses potential for inducing experimental diabetes and is also employed for islet staining.

Dithizone

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Catalog No. TXB-00004Alias DiphenylthiocarbazoneCas No. 60-10-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$48	Inquiry	Inquiry

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Dithizone (Diphenylthiocarbazone, DTZ) is a sulphur-containing metal ligand for the separation and determination of trace metal ions. It possesses potential for inducing experimental diabetes and is also employed for islet staining.
In vitro	Dithizone (0.2 mM, 5-10 minutes) stains isolated canine and porcine islet cells red, whereas under the same conditions, bovine islet cells do not exhibit coloration [1]. When islet cells stained with Dithizone (0.4 mM) are subsequently exposed to 300 μg/mL of 8-hydroxyquinoline, the original staining gradually fades within 5-10 minutes [1]. Prolonged exposure of islet cells to Dithizone (20 μg/mL) for 4-48 hours results in decreased insulin secretion and induces islet cell death [1].
Synonyms	Diphenylthiocarbazone

Chemical Properties

Molecular Weight	256.33
Formula	C₁₃H₁₂N₄S
Cas No.	60-10-6
Smiles	S=C(/N=N/C1=CC=CC=C1)NNC2=CC=CC=C2
Color	Black
Appearance	Solid

Storage & Solubility Information

Storage

store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (156.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (7.8 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9012 mL	19.5061 mL	39.0122 mL	195.0611 mL
5 mM	0.7802 mL	3.9012 mL	7.8024 mL	39.0122 mL
10 mM	0.3901 mL	1.9506 mL	3.9012 mL	19.5061 mL
20 mM	0.1951 mL	0.9753 mL	1.9506 mL	9.7531 mL
50 mM	0.0780 mL	0.3901 mL	0.7802 mL	3.9012 mL
100 mM	0.0390 mL	0.1951 mL	0.3901 mL	1.9506 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc