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LDCA

🥰Excellent
Catalog No. T60400Cas No. 349106-80-5

LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis. lDCA has a pronounced effect in cancer cells and does not show toxicity.

LDCA

LDCA

🥰Excellent
Purity: 99.19%
Catalog No. T60400Cas No. 349106-80-5
LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis. lDCA has a pronounced effect in cancer cells and does not show toxicity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$41In StockIn Stock
25 mg$83In StockIn Stock
50 mg$138In StockIn Stock
100 mg$223In StockIn Stock
200 mg$317-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.19%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis. lDCA has a pronounced effect in cancer cells and does not show toxicity.
In vitro
LDCA (2-100 μM ; 16-72 h) and Doxorubicin combination synergistically inhibit tumor progression. 15% death when cells were exposed to LDCA individually and caused 40% melanoma cell death combination synergistically with doxorubicin.[1]
In vivo
LDA (2 mg/kg, iv., 6 days ; once) combination with doxorubicin effectively alleviated tumor necrosis in mice and significantly improved their survival ability, leading to sustained limitations in tumor growth kinetics.[1]
Chemical Properties
Molecular Weight256.49
FormulaC8H5Cl3FNO
Cas No.349106-80-5
SmilesN(C(C(Cl)Cl)=O)C1=CC(Cl)=C(F)C=C1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90 mg/mL (350.89 mM), Sonication and heating to 60℃ are recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (12.87 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8988 mL19.4939 mL38.9879 mL194.9394 mL
5 mM0.7798 mL3.8988 mL7.7976 mL38.9879 mL
10 mM0.3899 mL1.9494 mL3.8988 mL19.4939 mL
20 mM0.1949 mL0.9747 mL1.9494 mL9.7470 mL
50 mM0.0780 mL0.3899 mL0.7798 mL3.8988 mL
100 mM0.0390 mL0.1949 mL0.3899 mL1.9494 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

LDHAApoptosis
Related Tags: buy LDCA | purchase LDCA | LDCA cost | order LDCA | LDCA chemical structure | LDCA in vivo | LDCA in vitro | LDCA formula | LDCA molecular weight
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