HSPG2 Protein, Human, Recombinant (His & Myc)

Name: HSPG2 Protein, Human, Recombinant (His & Myc)
Brand: TargetMol
SKU: TMPH-00996
Rating: 4.5 (1 reviews)

(Synonyms: Perlecan (PLC), HSPG2, HSPG, Basement membrane-specific heparan sulfate proteoglycan core protein) Copy Product Info

Synonyms: Perlecan (PLC), HSPG2, HSPG, Basement membrane-specific heparan sulfate proteoglycan core protein

Catalog No. TMPH-00996 Copy Product Info

HSPG2 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$219	20 days	20 days
10 µg	$365	20 days	20 days
20 µg	$613	20 days	20 days
50 µg	$1,160	20 days	20 days
100 µg	$1,890	20 days	20 days
200 µg	$2,890	20 days	20 days
500 µg	$5,160	20 days	20 days
1 mg	$7,960	20 days	20 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:94%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	HSPG2 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
Species	Human
Expression System	HEK293 Cells
Tag	N-10xHis, C-Myc
Accession Number	P98160
Amino Acid	DAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRAQAGANTRPCPS
Construction	4197-4391 aa
Protein Purity	> 85% as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Tris-based buffer, 50% glycerol
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	Perlecan (PLC), HSPG2, HSPG, Basement membrane-specific heparan sulfate proteoglycan core protein
Research Background	Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.; Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.; The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.

Chemical Properties

Molecular Weight

25.6 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.