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Homocarnosine acetate

Name: Homocarnosine acetate
Brand: TargetMol
SKU: T32098L
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T32098L

Homocarnosine acetate is a dipeptide unique to brain consisting of γ-aminobutyric acid (GABA) and histidine. Homocarnosine acetate has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation

Homocarnosine acetate

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Purity: 99.52%

Catalog No. T32098L

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	-	In Stock
2 mg	$72	-	In Stock
5 mg	$111	In Stock	In Stock
10 mg	$176	In Stock	In Stock
25 mg	$352	In Stock	In Stock
50 mg	$492	-	In Stock
100 mg	$696	-	In Stock
200 mg	$938	-	In Stock
1 mL x 10 mM (in DMSO)	$140	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.52%

Appearance:Solid

Color:White

Resource Download

COA HPLC

Product Introduction

Bioactivity

Description

In vitro

Homocarnosine acetate possesses greater tolerance to degradation by serum carnosinase relative to Carnosine. Homocarnosine acetate is known to be exclusively present in brain and cerebrospinal fluid and acts as a neuroprotective agent in a broad range of disease conditions. Homocarnosine acetate exerts antioxidant activity and prevent DNA oxidative damage to a similar extent as Carnosine[1]. Homocarnosine acetate is composed of γ-aminobutyric acid (GABA) and histidine and has a similar structure to Carnosine, with the only difference being an extra carbon atom in GABA compared to that in β-alanine of carnosine[1].

Chemical Properties

Molecular Weight	300.31
Formula	C₁₂H₂₀N₄O₅
Smiles	CC(O)=O.O=C(O)[C@H](CC1=CNC=N1)NC(CCCN)=O
Sequence	deamino-Dab-His
Sequence Short	XH

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (166.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3299 mL	16.6495 mL	33.2989 mL	166.4946 mL
5 mM	0.6660 mL	3.3299 mL	6.6598 mL	33.2989 mL
10 mM	0.3330 mL	1.6649 mL	3.3299 mL	16.6495 mL
20 mM	0.1665 mL	0.8325 mL	1.6649 mL	8.3247 mL
50 mM	0.0666 mL	0.3330 mL	0.6660 mL	3.3299 mL
100 mM	0.0333 mL	0.1665 mL	0.3330 mL	1.6649 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc