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Pozelimab
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Catalog No. T77121Cas No. 2096328-94-6
Alias REGN3918, REGN 3918
Pozelimab (REGN 3918) is a humanized antibody targeting component 5 (C5), used for research on Pozelimab disease.
Pozelimab
Pozelimab
😃Good
Catalog No. T77121Alias REGN3918, REGN 3918Cas No. 2096328-94-6
Pozelimab (REGN 3918) is a humanized antibody targeting component 5 (C5), used for research on Pozelimab disease.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $328 | - | In Stock | |
| 5 mg | $993 | - | In Stock | |
| 10 mg | $1,570 | - | In Stock | |
| 25 mg | $2,330 | - | In Stock | |
| 50 mg | $3,150 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.94% (SEC-HPLC)
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Product Introduction
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Chemical Properties
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| Description | Pozelimab (REGN 3918) is a humanized antibody targeting component 5 (C5), used for research on Pozelimab disease. |
| In vitro | The Kd values of Pozelimab binding to human C5 and cyborg monkey C5 were 262 pM and 8.55 nM, and the IC50 values were 2.8 nM and 20 nM, respectively. Pozelimab blocks alternative pathway (AP) -mediated hemolysis in normal and cynomolophoric monkeys with IC50 values of 26 and 8.9 nM, respectively. [1] |
| In vivo | Pozelimab (5 or 10 mg/kg, injected subcutaneously) has a half-life of 12.9-13.3 days in cynophilic monkeys. [2] Pozelimab (15 mg/kg, injected subcutaneously) showed prolonged pharmacokinetics and pharmacodynamics in both mice and cynophagous monkeys, and blocked complement mediated in vitro hemolysis activity for at least 35 days. [1] |
| Synonyms | REGN3918, REGN 3918 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Complement C5 |
| Molecular Weight | 144.78 kDa |
| Cas No. | 2096328-94-6 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG4SP kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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