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Pozelimab
(Synonyms: REGN3918, REGN 3918) Copy Product Info
🥰Excellent
Synonyms: REGN3918, REGN 3918
Catalog No. T77121 Copy Product Info
🥰Excellent
Pozelimab (REGN 3918) is a humanized antibody targeting component 5 (C5), used for research on Pozelimab disease.
Cas No. 2096328-94-6
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $328 | - | In Stock | |
| 5 mg | $993 | - | In Stock | |
| 10 mg | $1,570 | - | In Stock | |
| 25 mg | $2,330 | - | In Stock | |
| 50 mg | $3,150 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.94% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Pozelimab (REGN 3918) is a humanized antibody targeting component 5 (C5), used for research on Pozelimab disease. |
| In vitro | The Kd values of Pozelimab binding to human C5 and cyborg monkey C5 were 262 pM and 8.55 nM, and the IC50 values were 2.8 nM and 20 nM, respectively. Pozelimab blocks alternative pathway (AP) -mediated hemolysis in normal and cynomolophoric monkeys with IC50 values of 26 and 8.9 nM, respectively. [1] |
| In vivo | Pozelimab (5 or 10 mg/kg, injected subcutaneously) has a half-life of 12.9-13.3 days in cynophilic monkeys. [2] Pozelimab (15 mg/kg, injected subcutaneously) showed prolonged pharmacokinetics and pharmacodynamics in both mice and cynophagous monkeys, and blocked complement mediated in vitro hemolysis activity for at least 35 days. [1] |
| Synonyms | REGN3918, REGN 3918 |
| Reactivity | Human |
| Verified Activity | Immobilized Human Complement C5 Protein (His & Flag) (TMPY-05057) at 1 μg/mL (100 μL/well) can bind Pozelimab. The EC50 is 4.63 ng/mL. |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | Complement C5 |
| Molecular Weight | 144.78 kDa |
| Cas No. | 2096328-94-6 |
| Isotype | Human IgG4SP kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Pozelimab chemical structure | Pozelimab in vivo | Pozelimab in vitro | Pozelimab molecular weight
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