Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Tetrahydroalstonine

Name: Tetrahydroalstonine
Brand: TargetMol
SKU: TN2267
Rating: 4.5 (1 reviews)

😃Good

Catalog No. TN2267Cas No. 6474-90-4

Tetrahydroalstonine is an indole alkaloid extracted from the fruit of Rhazya stricta and is a selective α2-adrenoceptor antagonist. tetrahydroalstonine has shown antipsychotic activity in Rauwolfia tetraphylla.

Tetrahydroalstonine

😃Good

Catalog No. TN2267Cas No. 6474-90-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$569	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$442	7-10 days	7-10 days

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Resource Download

COA

Product Introduction

Bioactivity

Description	Tetrahydroalstonine is an indole alkaloid extracted from the fruit of Rhazya stricta and is a selective α2-adrenoceptor antagonist. tetrahydroalstonine has shown antipsychotic activity in Rauwolfia tetraphylla.
In vivo	The tetrahydroalstonine (0.5 to 2 mg/kg) on alpha 1- and alpha 2-adrenoceptors were assessed by effects on the rise in blood pressure induced by stimulation of the sympathetic outflow from the spinal cord or by injection of noradrenaline in pithed rats. Tetrahydroalstonine antagonized the effects of injected noradrenaline. Tetrahydroalstonine is more selective for alpha 2-adrenoceptors.[2]

Chemical Properties

Molecular Weight	352.43
Formula	C₂₁H₂₄N₂O₃
Cas No.	6474-90-4
Smiles	[H][C@@]12C[C@]3([H])C(=CO[C@@H](C)[C@]3([H])CN1CCc1c2[nH]c2ccccc12)C(=O)OC
Relative Density.	1.3 g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (255.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8374 mL	14.1872 mL	28.3744 mL	141.8721 mL
5 mM	0.5675 mL	2.8374 mL	5.6749 mL	28.3744 mL
10 mM	0.2837 mL	1.4187 mL	2.8374 mL	14.1872 mL
20 mM	0.1419 mL	0.7094 mL	1.4187 mL	7.0936 mL
50 mM	0.0567 mL	0.2837 mL	0.5675 mL	2.8374 mL
100 mM	0.0284 mL	0.1419 mL	0.2837 mL	1.4187 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc