4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant activity.

MAO-B:3.43 μM

4-Hydroxyderricin (100 microM) inhibited DNA synthesis in LLC cells, but it had no effect on the DNA synthesis in human umbilical vein endothelial cells (HUVECs) or on the adherence of LLC cells to HUVECs.
4-hydroxyderricin (50 mg/kg x 2/day) inhibited the reduction of the numbers of lymphocytes, CD4+, CD8+ and natural killer (NK)-T cells in the spleen of tumor-removed mice.[2]

4-Hydroxyderricin (50 mg/kg x 2/day; oral) inhibited the tumor growth in subcutaneous LLC-implanted mice and inhibited the lung metastasis and prolonged the survival time in mice after the removal of subcutaneous tumors by surgical operation.[2]
4-Hydroxyderricin (10 to 100 microM) inhibited Matrigel-induced formation of capillary-like tubes by HUVECs.[2]
The weights of the spleen and thymus in mice with subcutaneously implanted LLC were maintained close to those of normal mice by orally administered 4-hydroxyderricin.[2]