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dBRD9

Name: dBRD9
Brand: TargetMol
SKU: T31221
Price: 131 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T31221Cas No. 2170679-45-3

Alias dBRD-9, dBRD 9

dBRD9 is a PROTAC. dBRD9 is a double-acting molecule, partially containing Bromodomain-containing protein 9 (BRD9), ligand that recruits the cereblon E3 ubiquitin ligase. Ligand that recruits the cereblon E3 ubiquitin ligase. dBRD9 can inhibit the degradation of BRD9 in MOLM-13 cells, and the IC50 is 104 nM.

dBRD9

🥰Excellent

Purity: 99.81%

Catalog No. T31221Alias dBRD-9, dBRD 9Cas No. 2170679-45-3

Pack Size	Price	Availability
1 mg	$131	In Stock
5 mg	$328	In Stock
10 mg	$528	In Stock
25 mg	$920	In Stock
50 mg	$1,390	In Stock
100 mg	$1,930	In Stock
1 mL x 10 mM (in DMSO)	$457	In Stock

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Purity:99.81%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	dBRD9 is a PROTAC. dBRD9 is a double-acting molecule, partially containing Bromodomain-containing protein 9 (BRD9), ligand that recruits the cereblon E3 ubiquitin ligase. Ligand that recruits the cereblon E3 ubiquitin ligase. dBRD9 can inhibit the degradation of BRD9 in MOLM-13 cells, and the IC50 is 104 nM.
Targets&IC50	BRD9 (MOLM-13 cells):104 nM
In vitro	dBRD9 has prompt rapid BRD9 degradation over a broad range of concentrations. The degraded BRD9 showed significantly enhanced efficacy(10-to-100-fold). These findings reveal the tractability of non-BET bromodomain-containing proteins to chemical degradation and highlight lead compound dBRD9 as a tool for the study of BRD9[1].
In vivo	The final concentration of dBRD9 of 0.3 nM was mixed in silk fibroin hydrogel and injected into mice. It was found that BRD9 degradant alleviated ZOL-related ONJ. The ONJ-dBRD9 group is filled with well-organized newly formed trabecular bone, with 80% reduced incidence rate of osteonecrosis and periosteal reaction compared with the ONJ-control group[1].
Synonyms	dBRD-9, dBRD 9

Chemical Properties

Molecular Weight	783.83
Formula	C₄₀H₄₅N₇O₁₀
Cas No.	2170679-45-3
Smiles	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCNC(CN(CC4=C(OC)C=C(C=C4OC)C=5C=6C(C(=O)N(C)C5)=CN=CC6)C)=O
Relative Density.	1.357 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (114.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2758 mL	6.3789 mL	12.7579 mL	63.7893 mL
5 mM	0.2552 mL	1.2758 mL	2.5516 mL	12.7579 mL
10 mM	0.1276 mL	0.6379 mL	1.2758 mL	6.3789 mL
20 mM	0.0638 mL	0.3189 mL	0.6379 mL	3.1895 mL
50 mM	0.0255 mL	0.1276 mL	0.2552 mL	1.2758 mL
100 mM	0.0128 mL	0.0638 mL	0.1276 mL	0.6379 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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