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Isocorydine

Name: Isocorydine
Brand: TargetMol
SKU: T2832
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2832Cas No. 475-67-2

Alias Uzokoridin, S-(+)-Isocorydine, Luteanin, Artabotrin, (+)-Isocorynoline

S-Isocorydine (Uzokoridin)(+) and its derivatives have anticancer activities.

Isocorydine

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Purity: 99.90%

Catalog No. T2832Alias Uzokoridin, S-(+)-Isocorydine, Luteanin, Artabotrin, (+)-IsocorynolineCas No. 475-67-2

S-Isocorydine (Uzokoridin)(+) and its derivatives have anticancer activities.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$80	In Stock	In Stock
25 mg	$167	In Stock	In Stock
50 mg	$248	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.90%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Isocorydine AI Summary

Isocorydine exhibits a broad spectrum of bioactivities across various assays. It shows antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 and chloroquine-resistant Plasmodium falciparum W2 strains by inhibiting [3H]hypoxanthine uptake, with IC50 values of 1.9 µg/mL and 2.83 µg/mL, respectively. Additionally, it has antiplasmodial activity against multi-drug-resistant Plasmodium falciparum, with an IC50 of 37,000.0 nM, and antiamoebic activity against Entamoeba histolytica NIH 200 with an IC50 greater than 147,000.0 nM. The compound also exhibits antiviral properties by inhibiting SARS-CoV-2 induced cytotoxicity in VERO-6 cells with an IC50 value greater than 20,000.0 nM. Furthermore, Isocorydine demonstrates cytotoxicity against human KB cells with an IC50 greater than 733,000.0 nM and antiproliferative activity against human HepG2, HeLa, and MGC803 cells with an IC50 value greater than 200,000.0 nM. In addition to its antiparasitic and antiviral activities, the compound shows inhibition of CDK2 with an IC50 greater than 50,000.0 nM and demonstrates inhibition of sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells at a concentration of 10 µM. It also possesses inhibitory activity against several key enzymes including HSD17B4, JMJD2E, AmpC Beta-Lactamase, Cytochrome P450 3A4, Cytochrome P450 2C9, and Glutaminase (GLS), and modulates various biological processes such as lipid storage and differentiation in tumor cells. Isocorydine also shows efficacy in blocking the interaction between CBF-beta and RUNX1, inducing synthetic lethality in cells with 2HG production, inhibiting anthrax lethal toxin internalization, cell surface uPA generation, and inducing DNA re-replication in SW480 colon adenocarcinoma cells. Furthermore, it demonstrates potency in delaying death in malarial parasite plastids..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	S-Isocorydine (Uzokoridin)(+) and its derivatives have anticancer activities.
Synonyms	Uzokoridin, S-(+)-Isocorydine, Luteanin, Artabotrin, (+)-Isocorynoline

Chemical Properties

Molecular Weight	341.4
Formula	C₂₀H₂₃NO₄
Cas No.	475-67-2
Smiles	[H][C@@]12Cc3ccc(OC)c(O)c3-c3c(OC)c(OC)cc(CCN1C)c23
Relative Density.	1.222g/cm3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (29.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9291 mL	14.6456 mL	29.2912 mL	146.4558 mL
5 mM	0.5858 mL	2.9291 mL	5.8582 mL	29.2912 mL
10 mM	0.2929 mL	1.4646 mL	2.9291 mL	14.6456 mL
20 mM	0.1465 mL	0.7323 mL	1.4646 mL	7.3228 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc