CAMKK2 Protein, Human, Recombinant (GST)

Name: CAMKK2 Protein, Human, Recombinant (GST)
Brand: TargetMol
SKU: TMPC-00123
Rating: 4.5 (1 reviews)

(Synonyms: KIAA0787, CAMKKB, CAMKK2, CaM-KK beta, CaMKK beta, CaM-KK 2, CaMKK 2, CaM-kinase kinase beta, CaM-kinase kinase 2, Calcium/calmodulin-dependent protein kinase kinase 2) Copy Product Info

Synonyms: KIAA0787, CAMKKB, CAMKK2, CaM-KK beta, CaMKK beta, CaM-KK 2, CaMKK 2, CaM-kinase kinase beta, CaM-kinase kinase 2, Calcium/calmodulin-dependent protein kinase kinase 2

Catalog No. TMPC-00123 Copy Product Info

CAMKK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q96RR4.

Pack Size	Price	USA Stock	Global Stock	Quantity
10 µg	$1,390	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	The specific activity of CAMKK2 was determined to be 9-11 nmol /min/mg by radioactive kinase assay.
Description	CAMKK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is Q96RR4.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	Q96RR4
Construction	Recombinant full length human CAMKK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Protein Purity	>70% as determined by SDS-PAGE.
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Synonyms	KIAA0787, CAMKKB, CAMKK2, CaM-KK beta, CaMKK beta, CaM-KK 2, CaMKK 2, CaM-kinase kinase beta, CaM-kinase kinase 2, Calcium/calmodulin-dependent protein kinase kinase 2
Research Background	Ca2+calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a key regulator of nutrient intake, glucose metabolism, insulin production, and adipogenesis. This upstream activator of CaMKI, CaMKIV and AMP-activated protein kinase is inhibited by phosphorylation, which also triggers an association with the scaffolding protein 14-3-3. CaMKK isoforms differ in their 14-3-3-mediated regulations and that the interaction between 14-3-3 protein and the N-terminal 14-3-3-binding motif of CaMKK2 might be stabilized by small-molecule compounds. CaMKK2 plays a pivotal role in bone metabolism, fracture healing, and inflammation. CaMKK2 is a potent regulator of whole-body energy homeostasis and CaMKK2 may serve as a potential therapeutic target to treat skeletal diseases that underlie metabolic conditions and inflammation.

Chemical Properties

Molecular Weight

~88 kDa

Storage & Solubility Information

Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.