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Tryptophan-cholic acid

Name: Tryptophan-cholic acid
Brand: TargetMol
SKU: T207803
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T207803Cas No. 1630745-39-9

Alias Trp-CA

Tryptophan-cholic acid (Trp-CA) is a microbial amino acid-binding bile acid (MABA), serving as an endogenous ligand and agonist for MRGPRE (Mas-related GPCR family member E), thereby inducing GLP-1 secretion. Tryptophan-cholic acid improves glucose tolerance in diabetic mice and may be utilised for studies on type 2 diabetes.

Tryptophan-cholic acid

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Purity: 100%

Catalog No. T207803Alias Trp-CACas No. 1630745-39-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	-	In Stock
5 mg	$239	-	In Stock
10 mg	$388	-	In Stock
25 mg	$716	-	In Stock
50 mg	$1,130	-	In Stock
100 mg	$1,880	-	In Stock
200 mg	$2,570	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:100%

ee:100%

Appearance:Solid

Color:White

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COA LCMS HNMR ORP CSFC

Product Introduction

Bioactivity

Description	Tryptophan-cholic acid (Trp-CA) is a microbial amino acid-binding bile acid (MABA), serving as an endogenous ligand and agonist for MRGPRE (Mas-related GPCR family member E), thereby inducing GLP-1 secretion. Tryptophan-cholic acid improves glucose tolerance in diabetic mice and may be utilised for studies on type 2 diabetes.
Synonyms	Trp-CA

Chemical Properties

Molecular Weight	594.78
Formula	C₃₅H₅₀N₂O₆
Cas No.	1630745-39-9
Smiles	O[C@H]1[C@]2([C@]3([C@@](C)([C@@]([C@@H](CCC(N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(O)=O)=O)C)(CC3)[H])[C@@H](O)C[C@@]2([C@]6(C)[C@](C1)(C[C@H](O)CC6)[H])[H])[H])[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (134.5 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6813 mL	8.4065 mL	16.8129 mL	84.0647 mL
5 mM	0.3363 mL	1.6813 mL	3.3626 mL	16.8129 mL
10 mM	0.1681 mL	0.8406 mL	1.6813 mL	8.4065 mL
20 mM	0.0841 mL	0.4203 mL	0.8406 mL	4.2032 mL
50 mM	0.0336 mL	0.1681 mL	0.3363 mL	1.6813 mL
100 mM	0.0168 mL	0.0841 mL	0.1681 mL	0.8406 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc