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Tryptophan-cholic acid

🥰Excellent
Catalog No. T207803Cas No. 1630745-39-9
Alias Trp-CA

Tryptophan-cholic acid (Trp-CA) is a microbial amino acid-binding bile acid (MABA), serving as an endogenous ligand and agonist for MRGPRE (Mas-related GPCR family member E), thereby inducing GLP-1 secretion. Tryptophan-cholic acid improves glucose tolerance in diabetic mice and may be utilised for studies on type 2 diabetes.

Tryptophan-cholic acid

Tryptophan-cholic acid

🥰Excellent
Purity: 100%
Catalog No. T207803Alias Trp-CACas No. 1630745-39-9
Tryptophan-cholic acid (Trp-CA) is a microbial amino acid-binding bile acid (MABA), serving as an endogenous ligand and agonist for MRGPRE (Mas-related GPCR family member E), thereby inducing GLP-1 secretion. Tryptophan-cholic acid improves glucose tolerance in diabetic mice and may be utilised for studies on type 2 diabetes.
Pack SizePriceAvailabilityQuantity
1 mg$97In Stock
5 mg$239In Stock
10 mg$388In Stock
25 mg$716In Stock
50 mg$1,130In Stock
100 mg$1,880In Stock
200 mg$2,570In Stock
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Purity:100%
ee:100%
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Product Introduction

Bioactivity
Description
Tryptophan-cholic acid (Trp-CA) is a microbial amino acid-binding bile acid (MABA), serving as an endogenous ligand and agonist for MRGPRE (Mas-related GPCR family member E), thereby inducing GLP-1 secretion. Tryptophan-cholic acid improves glucose tolerance in diabetic mice and may be utilised for studies on type 2 diabetes.
SynonymsTrp-CA
Chemical Properties
Molecular Weight594.78
FormulaC35H50N2O6
Cas No.1630745-39-9
SmilesO[C@H]1[C@]2([C@]3([C@@](C)([C@@]([C@@H](CCC(N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(O)=O)=O)C)(CC3)[H])[C@@H](O)C[C@@]2([C@]6(C)[C@](C1)(C[C@H](O)CC6)[H])[H])[H])[H]
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (134.5 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6813 mL8.4065 mL16.8129 mL84.0647 mL
5 mM0.3363 mL1.6813 mL3.3626 mL16.8129 mL
10 mM0.1681 mL0.8406 mL1.6813 mL8.4065 mL
20 mM0.0841 mL0.4203 mL0.8406 mL4.2032 mL
50 mM0.0336 mL0.1681 mL0.3363 mL1.6813 mL
100 mM0.0168 mL0.0841 mL0.1681 mL0.8406 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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