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Antimalarial agent 59
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Catalog No. T217867 Copy Product Info
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Antimalarial agent 59 is an antimalarial compound that inhibits the growth of chloroquine-resistant Plasmodium falciparum strain FcB1 with an IC50 of 46 nM. Additionally, Antimalarial agent 59 exhibits cytotoxic activity against cancer cells and can be utilized in research related to malaria and ovarian cancer.
Antimalarial agent 59
Cas No. 3103602-12-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Antimalarial agent 59 is an antimalarial compound that inhibits the growth of chloroquine-resistant Plasmodium falciparum strain FcB1 with an IC50 of 46 nM. Additionally, Antimalarial agent 59 exhibits cytotoxic activity against cancer cells and can be utilized in research related to malaria and ovarian cancer. |
| In vitro | Antimalarial agent 59 (Compound 5i) effectively inhibits the growth of chloroquine-resistant Plasmodium falciparum FcB1 strain with an IC 50 of 46 nM and a selectivity index of 232. Within 72 hours, it impedes HeLa cervical cancer cell growth, with an LD 50 of 10.85 μM. In a concentration and time-dependent manner, it reduces the viability of A2780 ovarian cancer cells, achieving nearly complete inhibition at 10 μM for 48 and 72 hours. After 72 hours of incubation with this agent, A2780 cell growth is inhibited with an IC 50 of 3.82 ± 1.38 μM. Similarly, it decreases A549 lung adenocarcinoma cell viability, showing significant inhibition after 72 hours at 10 μM, with cell viability at 15.75%. |
| Molecular Weight | 340.37 |
| Formula | C17H24O7 |
| Cas No. | 3103602-12-3 |
| Smiles | O1OC2(OOC1C3=CC=C(OC)C(OC)=C3OC)CCC(C)CC2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Antimalarial agent 59 in vitro | Antimalarial agent 59 formula | Antimalarial agent 59 molecular weight
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