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Cbl-b-IN-30
Catalog No. T214011 Copy Product Info
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Cbl-b-IN-30 is an orally active inhibitor of Casitas B-lineage lymphoma-b (CBLB). It specifically binds to CBLB and inhibits its E3 ubiquitin ligase activity, with an IC50 value of 9.1 nM. Cbl-b-IN-30 promotes IL-2 secretion (EC50 value of 187.5 nM) and enhances T cell activation. This compound also exhibits antitumor activity and can induce immune memory. It is useful for colon cancer research.
Cbl-b-IN-30
Copy Product Info🥰Excellent
Catalog No. T214011
Cbl-b-IN-30 is an orally active inhibitor of Casitas B-lineage lymphoma-b (CBLB). It specifically binds to CBLB and inhibits its E3 ubiquitin ligase activity, with an IC50 value of 9.1 nM. Cbl-b-IN-30 promotes IL-2 secretion (EC50 value of 187.5 nM) and enhances T cell activation. This compound also exhibits antitumor activity and can induce immune memory. It is useful for colon cancer research.
Cbl-b-IN-30
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Cbl-b-IN-30 is an orally active inhibitor of Casitas B-lineage lymphoma-b (CBLB). It specifically binds to CBLB and inhibits its E3 ubiquitin ligase activity, with an IC50 value of 9.1 nM. Cbl-b-IN-30 promotes IL-2 secretion (EC50 value of 187.5 nM) and enhances T cell activation. This compound also exhibits antitumor activity and can induce immune memory. It is useful for colon cancer research. |
| In vitro | Cbl-b-IN-30 (Compound 10) enhances IL-2 secretion and T cell activation in human T cells activated by anti-CD3 antibody. It specifically binds to CBLB and inhibits its E3 ubiquitin ligase activity, with an IC50 value of 9.1 nM. Cbl-b-IN-30 shows no significant inhibition of CYP1A2/2C9/2C19/2D6/3A4 (IC50 >50 μM), has an IC50 >30 μM for hERG, and exhibits low risk for drug interactions and cardiac safety issues. |
| In vivo | Cbl-b-IN-30 (Compound 10) administered orally at doses of 3-30 mg/kg once daily for 15 days, inhibits tumor growth in BALB/c mice with syngeneic CT26 tumors. When used at 30 mg/kg orally once a day for 15 days in combination with anti-PD-1 antibody treatment, it induces lasting immune memory in BALB/c mice, as evidenced by no tumor growth and 100% survival upon rechallenge with CT26 cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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